ArticleArthritis & rheumatology (Hoboken, N.J.)2016
A Point-of-Care Raman Spectroscopy-Based Device for the Diagnosis of Gout and Pseudogout: Comparison With the Clinical Standard Microscopy.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Miniaturisation of Raman spectroscopy systems: from benchtop to backpocket.Lab on a chip · 2026Review
- An objective diagnosis of gout and calcium pyrophosphate deposition disease with machine learning of Raman spectra acquired in a point-of-care setting.Rheumatology (Oxford, England) · 2025Article
- Calcium Pyrophosphate Crystal Formation and Deposition: Where Do we Stand and What Does the Future hold?Current rheumatology reports · 2024Review
- Calcium pyrophosphate deposition disease: historical overview and potential gaps.Frontiers in medicine · 2024Review
- Identification of Uric Acid Crystals Accumulation in Human and Animal Tissues Using Combined Morphological and Raman Spectroscopy Analysis.Diagnostics (Basel, Switzerland) · 2022Article
- Portable, multi-modal Raman and fluorescence spectroscopic platform for point-of-care applications.Journal of biomedical optics · 2022Article
- Disposable Paper-Based Biosensors: Optimizing the Electrochemical Properties of Laser-Induced Graphene.ACS applied materials & interfaces · 2022Article
- A glance into the future of gout.Therapeutic advances in musculoskeletal disease · 2022Review
- Chondrocalcinosis: Advances in Diagnostic Imaging.Current rheumatology reports · 2021Review
- "Lessons from Rare Forms of Osteoarthritis".Calcified tissue international · 2021Review
- Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering.Theranostics · 2021Article
- Detection of Bacterial and Viral Pathogens Using Photonic Point-of-Care Devices.Diagnostics (Basel, Switzerland) · 2020Review
- Rapid detection of the aspergillosis biomarker triacetylfusarinine C using interference-enhanced Raman spectroscopy.Analytical and bioanalytical chemistry · 2020Article
- Dual-energy computed-tomography-based discrimination between basic calcium phosphate and calcium pyrophosphate crystal depositionTherapeutic advances in musculoskeletal disease · 2020Article
- Are the days of missed or delayed diagnosis of gout over?Nature reviews. Rheumatology · 2019Article
- Raman spectroscopy applications in rheumatology.Lasers in medical science · 2019Review
- Diagnostic advances in synovial fluid analysis and radiographic identification for crystalline arthritis.Current opinion in rheumatology · 2019Review
- Review: Unmet Needs and the Path Forward in Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition.Arthritis & rheumatology (Hoboken, N.J.) · 2018Review
- Systematic review and quality analysis of emerging diagnostic measures for calcium pyrophosphate crystal deposition disease.RMD open · 2016Article
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8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo demonstrate the usefulness of a novel medical device based on Raman spectroscopy for the rapid point-of-care diagnosis of gout and pseudogout.
methodsA shoebox-sized point-of-care Raman spectroscopy (POCRS) device was developed for use in the diagnosis of gout and pseudogout. The device included a disposable syringe microfiltration kit to collect arthropathic crystals from synovial fluid and a customized automated Raman spectroscopy system to chemically identify crystal species. Diagnosis according to the findings of POCRS was compared with the clinical standard diagnosis based on compensated polarized light microscopy (CPLM) of synovial fluid aspirates collected from symptomatic patients (n = 174). Kappa coefficients were used to measure the agreement between POCRS and CPLM findings.
resultsOverall, POCRS and CPLM results were consistent in 89.7% of samples (156 of 174). For the diagnosis of gout, the kappa coefficient for POCRS and CPLM was 0.84 (95% confidence interval [95% CI] 0.75-0.94). For the diagnosis of pseudogout, the kappa coefficient for POCRS and CPLM was 0.61 (95% CI 0.42-0.81).
conclusionKappa coefficients indicated that there was excellent agreement between POCRS and CPLM for the diagnosis of gout, with good agreement for the diagnosis of pseudogout. The POCRS device holds the potential to standardize and expedite the time to clinical diagnosis of gout and pseudogout, especially in settings where certified operators trained for CPLM analysis are not available.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.