ArticleCancer2016
Dispositional optimism and therapeutic expectations in early-phase oncology trials.
Article in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Clinical Trials: Understanding Patient Perspectives and Beliefs About Treatment.Clinical journal of oncology nursing · 2019Trial
- Patient preferences for pancreatic cancer treatment (PERSEUS): a multicenter discrete choice experiment.Health and quality of life outcomes · 2025Article
- Oncologists' knowledge, practices and ethical opinions about therapeutic misconception: a French national survey.BMC medical ethics · 2025Article
- Parents' expectations, preferences, and recall of germline findings in a childhood cancer precision medicine trial.Cancer · 2023Article
- Article
- The relationship between hope, medical expenditure and survival among advanced cancer patients.Frontiers in psychology · 2023Article
- Dispositional optimism and optimistic bias: Associations with cessation motivation, confidence, and attitudes.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022Article
- Influence of Dispositional Optimism on Ethically Salient Research Perspectives: A Pilot Study.Ethics & human research · 2022Article
- Health Behaviours and the Sense of Optimism in Nursing Students in Poland, Spain and Slovakia during the COVID-19 Pandemic.International journal of environmental research and public health · 2022Article
- Factors Influencing Perceived Helpfulness and Participation in Innovative Research: A Pilot Study of Individuals with and without Mood Symptoms.Ethics & behavior · 2022Article
- Differences in patient perceptions of integrated care among black, hispanic, and white Medicare beneficiaries.Health services research · 2021Article
- Perceived protectiveness of research safeguards and influences on willingness to participate in research: A novel MTurk pilot study.Journal of psychiatric research · 2021Article
- Comparative ethnographies of medical research: materiality, social relations, citizenship and hope in Tanzania and Sierra Leone.International health · 2020Article
- Spirituality in cancer patients on phase 1 clinical trials.Psycho-oncology · 2020Article
- Lack of Availability and Efficacy of Phase I and Basket Trials for Patients With Gastrointestinal Cancers.Journal of the National Cancer Institute · 2020Article
- Application of protection motivation theory to clinical trial enrolment for pediatric chronic conditions.BMC pediatrics · 2020Article
- Negative association of perceived risk and willingness to participate in innovative psychiatric research protocols.Journal of psychiatric research · 2020Article
- "Balancing Expectations with Actual Realities": Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial.Journal of personalized medicine · 2020Article
- Optimism may moderate screening mammogram frequency in Medicare: A longitudinal study.Medicine · 2019Observational
- Well-Being of Child and Family Participants in Phase 1 Pediatric Oncology Clinical Trials.Oncology nursing forum · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundPrior research has identified unrealistic optimism as a bias that might impair informed consent among patient-subjects in early-phase oncology trials. However, optimism is not a unitary construct; it also can be defined as a general disposition, or what is called dispositional optimism. The authors assessed whether dispositional optimism would be related to high expectations for personal therapeutic benefit reported by patient-subjects in these trials but not to the therapeutic misconception. The authors also assessed how dispositional optimism related to unrealistic optimism.
methodsPatient-subjects completed questionnaires designed to measure expectations for therapeutic benefit, dispositional optimism, unrealistic optimism, and the therapeutic misconception.
resultsDispositional optimism was found to be significantly associated with higher expectations for personal therapeutic benefit (Spearman rank correlation coefficient [r], 0.333; P<.0001), but was not associated with the therapeutic misconception (Spearman r, -0.075; P = .329). Dispositional optimism was found to be weakly associated with unrealistic optimism (Spearman r, 0.215; P = .005). On multivariate analysis, both dispositional optimism (P = .02) and unrealistic optimism (P<.0001) were found to be independently associated with high expectations for personal therapeutic benefit. Unrealistic optimism (P = .0001), but not dispositional optimism, was found to be independently associated with the therapeutic misconception.
conclusionsHigh expectations for therapeutic benefit among patient-subjects in early-phase oncology trials should not be assumed to result from misunderstanding of specific information regarding the trials. The data from the current study indicate that these expectations are associated with either a dispositionally positive outlook on life or biased expectations concerning specific aspects of trial participation. Not all manifestations of optimism are the same, and different types of optimism likely have different consequences for informed consent in early-phase oncology research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.