ReviewCurrent pharmaceutical design2016
Interrelationship Between Periapical Lesion and Systemic Metabolic Disorders.
Review in Current pharmaceutical design, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- The association between poor glycemic control and apical periodontitis: A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2026Pooled it
- Increased Prevalence of Periapical Lesions in Osteoporosis Patients: A Systematic Review.European endodontic journal · 2025Pooled it
- Application and performance of artificial intelligence-based models in the detection, segmentation and classification of periapical lesions: a systematic review.Frontiers in dental medicine · 2025Pooled it
- Impact of chronic diseases on the periapical health of endodontically treated teeth: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Adjuvant therapy with a 980-nm diode laser in root canal retreatment: randomized clinical trial with 1-year follow-up.Lasers in medical science · 2023Trial
- The relationship of apical periodontitis with chronic diseases and smoking habits: an umbrella review.Odontology · 2026Review
- Bioactive peptides in Endodontic infections: The Good, The Bad, and The Ugly.Probiotics and antimicrobial proteins · 2026Review
- Tissue-adhesive hydrogel-MXene biosensor for in situ intraoral TNF-α detection.Science advances · 2026Article
- The Potential Association Between Betel Nut Consumption and Apical Periodontitis: A Multicenter Cross-Sectional Study.International journal of dentistry · 2026Article
- Porphyromonas gingivalis-induced glucose intolerance during periapical lesions requires its LPS throught a Th17 immune response.International journal of oral science · 2025Article
- Metallomic characterization of induced periapical lesions-In vivo study.International endodontic journal · 2025Article
- Clinical and Radiological Markers of Periodontal Status and Risk of Cognitive Decline and Incident Dementia.Journal of clinical periodontology · 2025Article
- Effects of Combined Periodontal, Endodontic, and Dentoalveolar Surgical Treatments on Laboratory Parameters in Patients with Hyperlipidemia-A Clinical Interventional Study.Journal of clinical medicine · 2025Article
- Leveraging Pretrained Transformers for Efficient Segmentation and Lesion Detection in Cone-Beam Computed Tomography Scans.Journal of endodontics · 2024Article
- Effect of apical foraminal enlargement on postoperative pain and inflammatory markers in asymtomatic single-rooted mandibular teeth with apical periodontitis - AnJournal of conservative dentistry and endodontics · 2024Article
- The importance of mechanosensitive cell mediated prostaglandin and nitric oxide synthesis in the pathogenesis of apical periodontitis: comparative with chronic periodontitis.Clinical oral investigations · 2024Article
- Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoEInternational journal of oral science · 2024Article
- A 980 nm Diode Laser as an Adjunctive Therapy on the Healing of Apical Periodontitis Following Endodontic Retreatment: A Randomized Controlled Clinical Trial Study.Journal of lasers in medical sciences · 2024Article
- Article
- Interaction between apical periodontitis and systemic disease (Review).International journal of molecular medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPeriapical periodontitis, also known as periapical lesion, is a common dental disease, along with periodontitis (gum disease). Periapical periodontitis is a chronic inflammatory disease, caused by endodontic infection, and its development is regulated by the host immune/inflammatory response. Metabolic disorders, which are largely dependent on life style such as eating habits, have been interpreted as a "metabolically-triggered" low-grade systemic inflammation and may interact with periapical periodontitis by triggering immune modulation. The host immune system is therefore considered the common fundamental mechanism of both disease conditions.
methodWe have reviewed >200 articles to discuss the interrelationship between periapical lesions and metabolic disorders including type 2 diabetes mellitus, hypertension, and non-alcoholic fatty liver diseases (NAFLD), and their common pathological background in immunology/osteoimmunology and cytokine biology.
resultsAn elevated inflammatory state caused by metabolic disorders can impact the clinical outcome of periapical lesions and interfere with wound healing after endodontic treatment. Although additional well-designed clinical studies are needed, periapical lesions appear to affect insulin sensitivity and exacerbate non-alcoholic steatohepatitis.
conclusionImmune regulatory cytokines produced by various cell types, including immune cells and adipose tissue, play an important role in this interrelationship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.