Evidence map›Paper›PMID 26881229›Full record

ArticleBioMed research international2016

Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females.

Alaa Mohammed Ali, Huda AbdulKareem, Mohammad Al Anazi, Narasimha Reddy Parine, Jilani Purusottapatnam Shaik, Abdullah Alamri, Akbar Ali Khan Pathan, Arjumand Warsy

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 5 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
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  12. Polymorphism of XRCC3 in Egyptian Breast Cancer Patients.Pharmacogenomics and personalized medicine · 2020
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  14. Journal of oncology · 2019
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  15. Genetic Variations of DNA Repair Genes in Breast Cancer.Pathology oncology research : POR · 2019
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  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alaa Mohammed AliDepartment of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Huda AbdulKareemComprehensive Cancer Center, Department of Women's Imaging, King Fahad Medical City, Riyadh, Saudi Arabia.
Mohammad Al AnaziDepartment of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Narasimha Reddy ParineGenome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Jilani Purusottapatnam ShaikGenome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Abdullah AlamriGenome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Akbar Ali Khan PathanGenome Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Arjumand WarsyDepartment of Biochemistry, Center for Science and Medical Studies for Girls, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.ORCID 0000-0001-6957-203X
King Saud University · SAKing Fahd Medical City · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated three common polymorphisms (SNPs) in the XRCC3 gene (rs861539, rs1799794, and rs1799796) in 143 Saudi females suffering from breast cancer (median age = 51.4 years) and 145 age matched normal healthy controls. DNA was extracted from whole blood and genotyping was conducted using PCR-RFLP. rs1799794 showed significant association, where AA and AA+AG occurred at a significantly higher frequency in the cancer patients compared to the control group (OR: 28.1; 95% CI: 3.76-21.12; χ (2): 22.82; p < 0.0001). The G allele was protective and presented with a dominant model. The genotype and allele frequencies of rs861539 C>T and rs1799796 A>G did not show a significant difference when the results in the patients and controls were compared. However, the frequency of rs1799796 differed significantly in patients with different age of diagnosis, tumor grade, and ER and HER2 status. The wild type A allele occurred at a higher frequency in the ER- and HER2- group. Our results among Saudis suggest that some variations in XRCC3 may contribute to breast cancer susceptibility. In conclusion, the results obtained during this study suggest that rs1799794 in XRCC3 shows strong association with breast cancer development in Saudi females.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseAdultAgedAllelesBreast NeoplasmsDNA-Binding ProteinsFemaleGenotypeHumansMiddle AgedPolymorphism, Single NucleotideSaudi ArabiaDNA-Binding ProteinsX-ray repair cross complementing protein 3

Identifiers

PMID26881229
PMCPMC4736606
OpenAlexW2230978303

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.