ReviewNeural plasticity2016
Are Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression.
Review in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Brain Aging in Specific Phobia: An ENIGMA-Anxiety Mega-Analysis.Human brain mapping · 2026Pooled it
- Support for midlife anxiety diagnosis as an independent risk factor for dementia: a systematic review.BMJ open · 2018Pooled it
- 1,8-Cineole (Eucalyptol) in Neurodegeneration: From Pharmacological Mechanisms to Therapeutic Applications.Cells · 2026Review
- Brain Ageing in Social Anxiety Disorder: An ENIGMA-Anxiety Mega-Analysis Across 26 International Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Impaired slow-wave sleep accounts for brain aging-related increases in anxiety.Communications psychology · 2026Article
- Behavioral phenotypes in aging: structured exploratory computational analysis of multi-assay behavioral data.Frontiers in behavioral neuroscience · 2026Article
- Oxidative stress and cognitive function in Chinese patients with major depressive disorder: the mediating role of depression severity.BMC psychiatry · 2025Article
- Article
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- Age-related behavioural abnormalities in C57BL/6.KOR-Translational neuroscience · 2025Article
- Benefits of Quercetin on Glycated Hemoglobin, Blood Pressure, PiKo-6 Readings, Night-Time Sleep, Anxiety, and Quality of Life in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.Journal of clinical medicine · 2024Article
- Article
- Psychosocial Stress Modifies the Acute Cardiac Health Effects of Traffic-Related Air Pollution.Environment & health (Washington, D.C.) · 2024Article
- Examining the relationship between anxiety and regional brain volumes in the National Alzheimer's Coordinating Center uniform, imaging, and biomarker datasets.Cerebral circulation - cognition and behavior · 2024Article
- A longitudinal examination of the protective effect of resilience against anxiety among older adults with high COVID-related worry.Cognitive behaviour therapy · 2023Article
- Anxiety disorders are associated with reduced bone mineral density in men: Findings from the Geelong Osteoporosis Study.Acta psychiatrica Scandinavica · 2023Article
- Age-related changes in mice behavior and the contribution of lipocalin-2.Frontiers in aging neuroscience · 2023Article
- Independent replication of advanced brain age in mild cognitive impairment and dementia: detection of future cognitive dysfunction.Molecular psychiatry · 2022Article
- A comparative study of anti-aging effects ofJournal of clinical and translational research · 2022Article
- Anxiety disorders and age-related changes in physiology.The British journal of psychiatry : the journal of mental science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety disorders (AnxDs) are highly prevalent throughout the lifespan, with detrimental effects on daily-life functioning, somatic health, and quality of life. An emerging perspective suggested that AnxDs may be associated with accelerated aging. In this paper, we explored the association between AnxDs and hallmarks of accelerated aging, with a specific focus on neuroprogression. We reviewed animal and human findings that suggest an overlap between processes of impaired neurogenesis, neurodegeneration, structural, functional, molecular, and cellular modifications in AnxDs, and aging. Although this research is at an early stage, our review suggests a link between anxiety and accelerated aging across multiple processes involved in neuroprogression. Brain structural and functional changes that accompany normal aging were more pronounced in subjects with AnxDs than in coevals without AnxDs, including reduced grey matter density, white matter alterations, impaired functional connectivity of large-scale brain networks, and poorer cognitive performance. Similarly, molecular correlates of brain aging, including telomere shortening, Aβ accumulation, and immune-inflammatory and oxidative/nitrosative stress, were overrepresented in anxious subjects. No conclusions about causality or directionality between anxiety and accelerated aging can be drawn. Potential mechanisms of this association, limitations of the current research, and implications for treatments and future studies are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.