ArticleNeural plasticity2016
Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain.
Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Diffusion Tensor Imaging of Central Auditory Pathways in Patients with Sensorineural Hearing Loss: A Systematic Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2018Pooled it
- Altered regional homogeneity in patients with diabetic vitreous hemorrhage.World journal of diabetes · 2020Trial
- Pathways of Cross-Modal Access to the Visual Cortex in Late Blindness.Research square · 2026Article
- Functional reorganization of the visual cortex in blindness: a connectivity perspective.Frontiers in human neuroscience · 2026Review
- Reduced lateralization of the language network in the blind and its relationship with white matter tract neuroanatomy.Frontiers in human neuroscience · 2024Article
- Reorganization of thalamocortical connections in congenitally blind humans.Human brain mapping · 2023Article
- Assessing the structure of the posterior visual pathway in bilateral macular degeneration.Scientific reports · 2023Article
- Brain structural plasticity in rats subjected to early binocular enucleation characterized by high resolution anatomical magnetic resonance imaging and diffusion tensor imaging.Magnetic resonance letters · 2023Article
- Diverging patterns of plasticity in the nucleus basalis of Meynert in early- and late-onset blindness.Brain communications · 2023Article
- Investigating the neurochemistry of the human visual system using magnetic resonance spectroscopy.Brain structure & function · 2022Review
- Gyrification in relation to cortical thickness in the congenitally blind.Frontiers in neuroscience · 2022Article
- Alteration of Degree Centrality in Adolescents With Early Blindness.Frontiers in human neuroscience · 2022Article
- Grey Matter Hypertrophy and Atrophy in Early-Blind Adolescents: A Surface-Based Morphometric Study.Disease markers · 2022Article
- Topologic Reorganization of White Matter Connectivity Networks in Early-Blind Adolescents.Neural plasticity · 2022Article
- The effect of congenital blindness on resting-state functional connectivity revisited.Scientific reports · 2021Observational
- Structural Differences Across Multiple Visual Cortical Regions in the Absence of Cone Function in Congenital Achromatopsia.Frontiers in neuroscience · 2021Article
- The Effect of Congenital and Acquired Bilateral Anophthalmia on Brain Structure.Neuro-ophthalmology (Aeolus Press) · 2021Article
- Neuroplasticity in cerebral visual impairment (CVI): Assessing functional vision and the neurophysiological correlates of dorsal stream dysfunction.Neuroscience and biobehavioral reviews · 2020Review
- Differences in the major fiber-tracts of people with congenital and acquired blindness.IS&T International Symposium on Electronic Imaging · 2020Article
- Motor fatigue is associated with asymmetric connectivity properties of the corticospinal tract in multiple sclerosis.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in microstructure and structural connectedness of WM in individuals with congenital or late-onset blindness relative to normally sighted controls. Diffusion tensor imaging (DTI) provided voxel-specific microstructural features of the tissue, while anatomical connectivity mapping (ACM) assessed the connectedness of each voxel with the rest of the brain. ACM yielded reduced anatomical connectivity in the corpus callosum in individuals with congenital but not late-onset blindness. ACM did not identify any brain region where blindness resulted in increased anatomical connectivity. DTI revealed widespread microstructural differences as indexed by a reduced regional fractional anisotropy (FA). Blind individuals showed lower FA in the primary visual and the ventral visual processing stream relative to sighted controls regardless of the blindness onset. The results show that visual deprivation shapes WM microstructure and anatomical connectivity, but these changes appear to be spatially dissociated as changes emerge in different WM tracts. They also indicate that regional differences in anatomical connectivity depend on the onset of blindness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.