Evidence map›Paper›PMID 26881112›Full record

ReviewNeural plasticity2016

Seeding Stress Resilience through Inoculation.

Archana Ashokan, Meenalochani Sivasubramanian, Rupshi Mitra

Abstract readReview
In one paragraph

Review in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
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  6. Review
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  9. Resilience and its association with caregiving and psychosocial factors among lung cancer caregivers in Vietnam.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
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  16. Maternal stress during the third trimester of pregnancy and the neonatal microbiome.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2023
    Article
  17. Responses to Reduced Feeding Frequency in Captive-Born Cheetahs (Animals : an open access journal from MDPI · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Archana AshokanSchool of Biological Sciences, Nanyang Technological University, Singapore 637551.
Meenalochani SivasubramanianSchool of Biological Sciences, Nanyang Technological University, Singapore 637551.
Rupshi MitraSchool of Biological Sciences, Nanyang Technological University, Singapore 637551.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress is a generalized set of physiological and psychological responses observed when an organism is placed under challenging circumstances. The stress response allows organisms to reattain the equilibrium in face of perturbations. Unfortunately, chronic and/or traumatic exposure to stress frequently overwhelms coping ability of an individual. This is manifested as symptoms affecting emotions and cognition in stress-related mental disorders. Thus environmental interventions that promote resilience in face of stress have much clinical relevance. Focus of the bulk of relevant neurobiological research at present remains on negative aspects of health and psychological outcomes of stress exposure. Yet exposure to the stress itself can promote resilience to subsequent stressful episodes later in the life. This is especially true if the prior stress occurs early in life, is mild in its magnitude, and is controllable by the individual. This articulation has been referred to as "stress inoculation," reminiscent of resilience to the pathology generated through vaccination by attenuated pathogen itself. Using experimental evidence from animal models, this review explores relationship between nature of the "inoculum" stress and subsequent psychological resilience.

Indexed as

Resilience, PsychologicalAdaptation, PsychologicalAnimalsBrainCorticosteroneFemaleHumansHypothalamusMaleModels, AnimalPituitary-Adrenal SystemStress, PsychologicalCorticosterone

Identifiers

PMID26881112
PMCPMC4736400

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.