Evidence map›Paper›PMID 26881111›Full record

ArticleNeural plasticity2016

Interhemispheric Plasticity following Intermittent Theta Burst Stimulation in Chronic Poststroke Aphasia.

Joseph C Griffis, Rodolphe Nenert, Jane B Allendorfer, Jerzy P Szaflarski

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06974279 (Precision Neuromodulation in Post-Stroke Aphasia Using TMS), which is not on this map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06974279 narecruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuromodulation in Post-Stroke Aphasia Using TMS

TypeinterventionalSponsorMedical College of WisconsinRan2025 to 2036Enrolled50ConditionsAphasia, Stroke, LanguageArmsPrecision TMS with SFA, Control TMS with SFA
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
  2. Trial
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  4. Diagnosing and managing post-stroke aphasia.Expert review of neurotherapeutics · 2021
    Trial
  5. Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia Therapy.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Trial
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Targeted neurorehabilitation strategies in post-stroke aphasia.Restorative neurology and neuroscience · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Joseph C GriffisDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL 35294-0021, USA.
Rodolphe NenertDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294-0021, USA.
Jane B AllendorferDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294-0021, USA.
Jerzy P SzaflarskiDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294-0021, USA; Department of Neurology, University of Cincinnati Academic Health Center, Cincinnati, OH, USA.
University of Alabama at Birmingham · US

Funding

Post-Stroke Aphasia and rTMS Treatment (PART) StudyR01HD068488 · NICHD · UNIVERSITY OF CINCINNATI · PI SZAFLARSKI, JERZY P · 2012 to 2016
$2.5M
NICHD NIH HHS R01 HD068488
6 · The paper itself

Abstract

The effects of noninvasive neurostimulation on brain structure and function in chronic poststroke aphasia are poorly understood. We investigated the effects of intermittent theta burst stimulation (iTBS) applied to residual language-responsive cortex in chronic patients using functional and anatomical MRI data acquired before and after iTBS. Lateralization index (LI) analyses, along with comparisons of inferior frontal gyrus (IFG) activation and connectivity during covert verb generation, were used to assess changes in cortical language function. Voxel-based morphometry (VBM) was used to assess effects on regional grey matter (GM). LI analyses revealed a leftward shift in IFG activity after treatment. While left IFG activation increased, right IFG activation decreased. Changes in right to left IFG connectivity during covert verb generation also decreased after iTBS. Behavioral correlations revealed a negative relationship between changes in right IFG activation and improvements in fluency. While anatomical analyses did not reveal statistically significant changes in grey matter volume, the fMRI results provide evidence for changes in right and left IFG function after iTBS. The negative relationship between post-iTBS changes in right IFG activity during covert verb generation and improvements in fluency suggests that iTBS applied to residual left-hemispheric language areas may reduce contralateral responses related to language production and facilitate recruitment of residual language areas after stroke.

Indexed as

Neuronal PlasticityAphasiaBrainChronic DiseaseFemaleFunctional LateralityHumansMagnetic Resonance ImagingMaleMiddle AgedPrefrontal CortexStrokeTranscranial Magnetic Stimulation

Identifiers

PMID26881111
PMCPMC4736997
OpenAlexW2224415849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.