Evidence map›Paper›PMID 26881109›Full record

ArticleNeural plasticity2016

N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth.

Joseph Gonzalez-Heydrich, Michelle Bosquet Enlow, Eugene D'Angelo, Larry J Seidman, Sarah Gumlak, April Kim, Kristen A Woodberry, Ashley Rober, Sahil Tembulkar, Kyle O'Donnell and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Joseph Gonzalez-HeydrichBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA.
Michelle Bosquet EnlowBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA.
Eugene D'AngeloBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA.
Larry J SeidmanDepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA; Department of Psychiatry, Commonwealth Research Center, Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, USA; Department of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Sarah GumlakBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
April KimBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Kristen A WoodberryDepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA; Department of Psychiatry, Commonwealth Research Center, Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, USA.
Ashley RoberBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Sahil TembulkarBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Kyle O'DonnellBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Hesham M HamodaBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA.
Kara KimballBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Alexander RotenbergBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Lindsay M ObermanNeuroplasticity and Autism Spectrum Disorder Program and Department of Psychiatry and Human Behavior, E.P. Bradley Hospital and Warren Alpert Medical School, Brown University, 1011 Veterans Memorial Parkway, East Providence, RI 02915, USA.
Alvaro Pascual-LeoneDepartment of Psychiatry, Commonwealth Research Center, Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Matcheri S KeshavanDepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA; Department of Psychiatry, Commonwealth Research Center, Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, USA.
Frank H DuffyBoston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Boston Children's Hospital · USHarvard University · USBeth Israel Deaconess Medical Center · USBrown University · USMassachusetts General Hospital · US

Funding

Cortical Plasticity in Autism Spectrum DisordersR01MH100186 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROTENBERG, ALEXANDER · 2014 to 2018
$2.2M
Innovative Intervention for Reducing Stress Reactivity and Risk for PsychosisK23MH102358 · NIMH · MAINEHEALTH · PI WOODBERRY, KRISTEN ANNE · 2014 to 2017
$722k
NIMH NIH HHS 1R01MH100186NIMH NIH HHS K23 MH102358NIMH NIH HHS R01 MH100186NIMH NIH HHS U01 MH08198-06A1
6 · The paper itself

Abstract

Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease's pathogenesis. The importance of plasticity in neurodevelopment implies a role for therapies that target these mechanisms in early life to prevent schizophrenia. Testing such therapies requires noninvasive methods that can assess engagement of target mechanisms. The auditory N100 is an obligatory cortical response whose amplitude decreases with tone repetition. This adaptation may index the health of plasticity mechanisms required for normal development. We exposed participants aged 5 to 17 years with psychosis (n = 22), at clinical high risk (CHR) for psychosis (n = 29), and healthy controls (n = 17) to an auditory tone repeated 450 times and measured N100 adaptation (mean amplitude during first 150 tones - mean amplitude during last 150 tones). N100 adaptation was reduced in CHR and psychosis, particularly among participants <13 years old. Initial N100 blunting partially accounted for differences. Decreased change in the N100 amplitude with tone repetition may be a useful marker of defects in neuroplastic mechanisms measurable early in life.

Indexed as

Adaptation, PhysiologicalEvoked Potentials, AuditoryNeuronal PlasticityAcoustic StimulationAdolescentBiomarkersCerebral CortexElectroencephalographyEvoked PotentialsFemaleHumansMaleSchizophreniaBiomarkers

Identifiers

PMID26881109
PMCPMC4737454
OpenAlexW2175341157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.