SynthesisNeural plasticity2016
Defining Optimal Aerobic Exercise Parameters to Affect Complex Motor and Cognitive Outcomes after Stroke: A Systematic Review and Synthesis.
Synthesis in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Effects of exercise dose based on the ACSM recommendations on patients with post-stroke cognitive impairment: a systematic review and meta-analyses.Frontiers in physiology · 2024Pooled it
- The effects of exercise intervention on cognition and motor function in stroke survivors: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2020Pooled it
- The Effect of Exercise Training on Gait, Balance, and Physical Fitness Asymmetries in Persons With Chronic Neurological Conditions: A Systematic Review of Randomized Controlled Trials.Frontiers in physiology · 2020Pooled it
- The Aphasia Physical EXercise (APEX) study: feasibility of a new high-intensity functional interval training for stroke survivors with aphasia.Aphasiology · 2026Article
- Cognitive and sensorimotor benefits of moderate- and high-intensity exercise are associated with specific expression of neurotrophic markers in older rats.Scientific reports · 2025Article
- The safety and feasibility of a pilot randomized clinical trial using combined exercise and neurostimulation for post-stroke pain: the EXERT-Stroke study.Frontiers in neurology · 2025Article
- Physical Activity and Cognitive Functioning.Medicina (Kaunas, Lithuania) · 2024Review
- Therapeutic Importance of Exercise in Neuroplasticity in Adults with Neurological Pathology: Systematic Review.International journal of exercise science · 2024Review
- The Critical Period After Stroke Study (CPASS) Upper Extremity Treatment Protocol.Archives of rehabilitation research and clinical translation · 2023Article
- Defining, quantifying, and reporting intensity, dose, and dosage of neurorehabilitative interventions focusing on motor outcomes.Frontiers in rehabilitation sciences · 2023Article
- Comparison of the Effects of Constraint-Induced Movement Therapy and Unconstraint Exercise on Oxidative Stress and Limb Function-A Study on Human Patients and Rats with Cerebral Infarction.Brain sciences · 2022Article
- The Stroke Recovery in Motion Implementation Planner: Mixed Methods User Evaluation.JMIR formative research · 2022Article
- The Effect of Endurance Training on Serum BDNF Levels in the Chronic Post-Stroke Phase: Current Evidence and Qualitative Systematic Review.Journal of clinical medicine · 2022Review
- Can exercise shape your brain? A review of aerobic exercise effects on cognitive function and neuro-physiological underpinning mechanisms.AIMS neuroscience · 2022Review
- Physical Activity and Sport for Acquired Brain Injury (PASABI): A Non-Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2021Article
- Effects of Exercise Intensity on Acute Circulating Molecular Responses Poststroke.Neurorehabilitation and neural repair · 2020Article
- A Short Bout of Exercise Prior to Stroke Improves Functional Outcomes by Enhancing Angiogenesis.Neuromolecular medicine · 2019Article
- Effect of aerobic exercise prior to modified constraint-induced movement therapy outcomes in individuals with chronic hemiparesis: a study protocol for a randomized clinical trial.BMC neurology · 2019Article
- The Effectiveness of Exercise on Cognitive Performance in Individuals with Known Vascular Disease: A Systematic Review.Journal of clinical medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although poststroke aerobic exercise (AE) increases markers of neuroplasticity and protects perilesional tissue, the degree to which it enhances complex motor or cognitive outcomes is unknown. Previous research suggests that timing and dosage of exercise may be important. We synthesized data from clinical and animal studies in order to determine optimal AE training parameters and recovery outcomes for future research. Using predefined criteria, we included clinical trials of stroke of any type or duration and animal studies employing any established models of stroke. Of the 5,259 titles returned, 52 articles met our criteria, measuring the effects of AE on balance, lower extremity coordination, upper limb motor skills, learning, processing speed, memory, and executive function. We found that early-initiated low-to-moderate intensity AE improved locomotor coordination in rodents. In clinical trials, AE improved balance and lower limb coordination irrespective of intervention modality or parameter. In contrast, fine upper limb recovery was relatively resistant to AE. In terms of cognitive outcomes, poststroke AE in animals improved memory and learning, except when training was too intense. However, in clinical trials, combined training protocols more consistently improved cognition. We noted a paucity of studies examining the benefits of AE on recovery beyond cessation of the intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.