ArticleBiochemistry research international2016
Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets.
Article in Biochemistry research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed.
- Expandable Nanocomposite Shape-Memory Hemostat for the Treatment of Noncompressible Hemorrhage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Deposition of Heavy Metals in Patients with Deep Venous Thrombosis and Healthy Individuals: A Case-Control Study with Laser-Induced Breakdown Spectroscopic Analysis of Nail Edges.Journal of clinical medicine · 2026Article
- OPSALC: On-Particle Solvent-Assisted Lipid Coating to Create Erythrocyte Membrane-like Coatings with Improved Hemocompatibility.ACS applied materials & interfaces · 2025Article
- Immunological properties of silica nanoparticles: a structure-activity relationship study.Nanotoxicology · 2024Article
- Effect of silica-sprayed collection tubes on synovial fluid bacterial culture.Veterinary medicine and science · 2024Article
- Application of non-metal nanoparticles, as a novel approach, for improving the stability of blood products: 2011-2021.Progress in biomaterials · 2022Review
- A novel murine in vivo model for acute hereditary angioedema attacks.Scientific reports · 2021Article
- Nanoparticle-Based Technology Approaches to the Management of Neurological Disorders.International journal of molecular sciences · 2020Review
- A New Antibiotic-Loaded Sol-Gel can Prevent Bacterial Intravenous Catheter-Related Infections.Materials (Basel, Switzerland) · 2020Article
- Silica nanomaterials induce organ injuries by CaParticle and fibre toxicology · 2020Article
- Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system.International journal of nanomedicine · 2018Article
- Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes.BioMed research international · 2018Article
- Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding.Advanced materials (Deerfield Beach, Fla.) · 2018Review
- Antiplatelet and anti-proliferative action of disintegrin from Echis multisquamatis snake venom.Croatian medical journal · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interaction of nanoparticles with the blood coagulation is important prior to their using as the drug carriers or therapeutic agents. The aim of present work was studying of the primary effects of silica nanoparticles (SiNPs) on haemostasis in vitro. We studied the effect of SiNPs on blood coagulation directly estimating the activation of prothrombin and factor X and to verify any possible effect of SiNPs on human platelets. It was shown that SiNPs shortened coagulation time in APTT and PT tests and increased the activation of factor X induced by RVV possibly due to the sorption of intrinsic pathway factors on their surface. SiNPs inhibited the aggregation of platelet rich plasma induced by ADP but in the same time partially activated platelets as it was shown using flow cytometry. The possibility of SiNPs usage in nanomedicine is strongly dependant on their final concentration in bloodstream and the size of the particles that are used. However SiNPs are extremely promising as the haemostatic agents for preventing the blood loss after damage.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.