Evidence map›Paper›PMID 26881067›Full record

ArticleJournal of obesity2015

A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.

Sandra J Hasstedt, Yuanpei Xin, Rong Mao, Tracey Lewis, Ted D Adams, Steven C Hunt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of obesity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sandra J HasstedtDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Yuanpei XinCardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Rong MaoDepartment of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA; ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA.
Tracey LewisARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA.
Ted D AdamsCardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Steven C HuntCardiovascular Genetics Division, University of Utah School of Medicine, Salt Lake City, UT 84112, USA; Department of Genetic Medicine, Weill Cornell Medical College in Qatar, Doha, Qatar.
University of Utah · USARUP Institute for Clinical and Experimental PathologyWeill Cornell Medical College in Qatar · QA

Funding

Using Copy Number Variation to Identify Severe Obesity Genes in Utah PedigreesR56DK082938 · NIDDK · UNIVERSITY OF UTAH · PI HUNT, STEVEN C. · 2010 to 2010
$670k
NIDDK NIH HHS DK082938NIDDK NIH HHS R56 DK082938
6 · The paper itself

Abstract

BACKGROUND/

objectivesTo identify copy number variants (CNVs) which are associated with body mass index (BMI). SUBJECTS/

methodsCNVs were identified using array comparative genomic hybridization (aCGH) on members of pedigrees ascertained through severely obese (BMI ≥ 35 kg/m(2)) sib pairs (86 pedigrees) and thin (BMI ≤ 23 kg/m(2)) probands (3 pedigrees). Association was inferred through pleiotropy of BMI with CNV log⁡2 intensity ratio.

resultsA 77-kilobase CNV on chromosome 20q13.3, confirmed by real-time qPCR, exhibited deletions in the obese subjects and duplications in the thin subjects (P = 2.2 × 10(-6)). Further support for the presence of a deletion derived from inference by likelihood analysis of null alleles for SNPs residing in the region.

conclusionsOne or more of 7 genes residing in a chromosome 20q13.3 CNV region appears to influence BMI. The strongest candidate is ARFRP1, which affects glucose metabolism in mice.

Indexed as

Body Mass IndexChromosomes, Human, Pair 20DNA Copy Number VariationsGenetic PleiotropyADP-Ribosylation FactorsAdultAgedAged, 80 and overAllelesComparative Genomic HybridizationFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleADP-Ribosylation FactorsARFRP1 protein, human

Identifiers

PMID26881067
PMCPMC4736014
OpenAlexW2203866206

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.