Evidence map›Paper›PMID 26881045›Full record

ArticleOxidative medicine and cellular longevity2016

Interplay between Superoxide Dismutase, Glutathione Peroxidase, and Peroxisome Proliferator Activated Receptor Gamma Polymorphisms on the Risk of End-Stage Renal Disease among Han Chinese Patients.

Chia-Ter Chao, Yen-Ching Chen, Chih-Kang Chiang, Jenq-Wen Huang, Cheng-Chung Fang, Chen-Chih Chang, Chung-Jen Yen

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chia-Ter ChaoDepartment of Medicine, National Taiwan University Hospital Jinshan Branch, New Taipei City, Taiwan; Graduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Section 1, 10051 Taipei, Taiwan.
Yen-Ching ChenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, No. 17 Xu-Zhou Road, 10055 Taipei, Taiwan.
Chih-Kang ChiangGraduate Institute of Toxicology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road, Section 1, 10051 Taipei, Taiwan; Department of Integrated Diagnostics & Therapeutics, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
Jenq-Wen HuangDepartment of Internal Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
Cheng-Chung FangDepartment of Emergency Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
Chen-Chih ChangDepartment of Internal Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
Chung-Jen YenDepartment of Internal Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan; Department of Geriatric Medicine and Gerontology, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 10002 Taipei, Taiwan.
National Taiwan University Hospital · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. Single nucleotide polymorphisms (SNPs) of antioxidants, including superoxide dismutase 2 (SOD2) and glutathione peroxidase 1 (GPX1), play an important role in the risk for cancer and metabolic disorders. However, little is known regarding the effect of antioxidant SNPs on renal events. Methods. We prospectively enrolled multicenter patients with end-stage renal disease (ESRD) and those without chronic kidney disease (CKD) of Han Chinese origin, with SOD2 (Val16Ala), GPX1 (Pro197Leu), and PPAR-γ (Pro12Ala, C161T) genotyped. Multiple regression analyses were conducted to evaluate the significant risk determinants for ESRD. Results. Compared to ESRD patients, non-CKD subjects were more likely to have T allele at SOD2 Val16Ala (p = 0.036) and CC genotype at PPAR-γ Pro12Ala (p = 0.028). Regression analysis showed that TT genotype of SOD2 Val16Ala conferred significantly lower ESRD risk among patients without diabetes (odds ratio 0.699; p = 0.018). GPX1 SNP alone did not alter the risk. We detected significant interactions between SNPs including PPAR-γ Pro12Ala, C161T, and GPX1 regarding the risk of ESRD. Conclusion. This is the first and largest study on the association between adverse renal outcomes and antioxidant SNPs among Han Chinese population. Determination of SOD2 and PPAR-γ SNPs status might assist in ESRD risk estimation.

Indexed as

Genetic Predisposition to DiseaseAsian PeopleCohort StudiesEthnicityFemaleGene FrequencyGlutathione PeroxidaseGlutathione Peroxidase GPX1HumansKidney Failure, ChronicLogistic ModelsMaleMiddle AgedMultivariate AnalysisPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthGlutathione PeroxidaseGlutathione Peroxidase GPX1GPX1 protein, humanPPAR gammaSuperoxide DismutaseSuperoxide Dismutase 2

Identifiers

PMID26881045
PMCPMC4736813
OpenAlexW2222500681

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.