Evidence map›Paper›PMID 26881032›Full record

ArticleOxidative medicine and cellular longevity2016

Mitochondrial Alterations in Peripheral Mononuclear Blood Cells from Alzheimer's Disease and Mild Cognitive Impairment Patients.

A Delbarba, G Abate, C Prandelli, M Marziano, L Buizza, N Arce Varas, A Novelli, F Cuetos, C Martinez, C Lanni and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  15. Novel Techniques for Mapping DNA Damage and Repair in the Brain.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

A DelbarbaDiadem Ltd., Spin Off of Brescia University, Brescia, Italy.
G AbateDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
C PrandelliDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
M MarzianoDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
L BuizzaDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
N Arce VarasDepartment of Psychology, University of Oviedo, Plaza Feijoo s/n, 33003 Oviedo, Spain.
A NovelliDepartment of Psychology, University of Oviedo, Plaza Feijoo s/n, 33003 Oviedo, Spain; Institute of Biotechnology, University of Oviedo, 33006 Oviedo, Spain.
F CuetosDepartment of Psychology, University of Oviedo, Plaza Feijoo s/n, 33003 Oviedo, Spain.
C MartinezCabueñes General Hospital, Calle Los Prados 395, Gijón, 33203 Asturias, Spain.
C LanniDepartment of Experimental and Applied Pharmacology, Centre of Excellence in Applied Biology, University of Pavia, Viale Taramelli 6, 27100 Pavia, Italy.
M MemoDepartment of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
D UbertiDiadem Ltd., Spin Off of Brescia University, Brescia, Italy; Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Brescia University · USUniversidad de Oviedo · ESUniversity of Brescia · ITCzech Academy of Sciences, Institute of Biotechnology · CZHospital Universitario De Cabueñes · ESUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well recognized that mitochondrial dysfunction contributes to neurodegeneration occurring in Alzheimer's disease (AD). However, evidences of mitochondrial defects in AD peripheral cells are still inconclusive. Here, some mitochondrial-encoded and nuclear-encoded proteins, involved in maintaining the correct mitochondria machine, were investigated in terms of protein expression and enzymatic activity in peripheral blood mononuclear cells (PBMCs) isolated from AD and Mild Cognitive Impairment (MCI) patients and healthy subjects. In addition mitochondrial DNA copy number was measured by real time PCR. We found some differences and some similarities between AD and MCI patients when compared with healthy subjects. For example, cytochrome C and cytochrome B were decreased in AD, while MCI showed only a statistical reduction of cytochrome C. On the other hand, both AD and MCI blood cells exhibited highly nitrated MnSOD, index of a prooxidant environment inside the mitochondria. TFAM, a regulator of mitochondrial genome replication and transcription, was decreased in both AD and MCI patients' blood cells. Moreover also the mitochondrial DNA amount was reduced in PBMCs from both patient groups. In conclusion these data confirmed peripheral mitochondria impairment in AD and demonstrated that TFAM and mtDNA amount reduction could be two features of early events occurring in AD pathogenesis.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseCase-Control StudiesCell NucleusCognitive DysfunctionCytochromes bCytochromes cDNA, MitochondrialFemaleGene DosageHumansLeukocytes, MononuclearMaleMiddle AgedMitochondriaCytochromes bCytochromes cDNA, MitochondrialOxidantsSuperoxide Dismutase

Identifiers

PMID26881032
PMCPMC4736772
OpenAlexW2223861606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.