ReviewOxidative medicine and cellular longevity2016
1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.
Review in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 88 citations in OpenAlex.
- Article
- Iron-catalyzed divergent synthesis of coumarin fused N-heterocyclesRSC advances · 2025Article
- A Decade of Catalytic Progress in 1,4-Dihydropyridines (1,4-DHPs) Synthesis (2016-2024).Current organic synthesis · 2025Article
- The Role of Antioxidants in the Therapy of Cardiovascular Diseases-A Literature Review.Nutrients · 2024Review
- Evaluation of diethyl 4-(5-bromo-1H-indol-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate: synthesis, anti-corrosion potential, and biomedical applications.BMC chemistry · 2024Article
- Lercanidipine's Antioxidative Effect Prevents Noise-Induced Hearing Loss.Antioxidants (Basel, Switzerland) · 2024Article
- Synthesis and characterization of new hexahydroquinoline derivatives and evaluation of their cytotoxicity, intracellular ROS production, and inhibitory effects on inflammatory mediators.Turkish journal of chemistry · 2024Article
- New 6'-Amino-5'-cyano-2-oxo-1,2-dihydro-1'Molecules (Basel, Switzerland) · 2023Article
- Genotoxic and genoprotective effects of 1,4-dihydropyridine derivatives: a brief review.Arhiv za higijenu rada i toksikologiju · 2023Review
- Molecular docking analysis of calcium channel blockers with ALR2 and RAGE.Bioinformation · 2023Article
- Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core.Molecules (Basel, Switzerland) · 2022Article
- Antioxidant and cytotoxic activities of selected salicylidene imines: experimental and computational study.Molecular diversity · 2022Article
- The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A.Pharmaceuticals (Basel, Switzerland) · 2021Article
- 1,4-dihydropyridine derivatives increase mRNA expression ofArhiv za higijenu rada i toksikologiju · 2021Article
- Synergistic Therapies as a Promising Option for the Treatment of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2020Review
- Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2020Article
- Regioselective Alkylation of Pyridinium Riboses.European journal of organic chemistry · 2020Article
- 4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action.Oxidative medicine and cellular longevity · 2020Article
- Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability ofBiomolecules · 2019Article
- Probing the mechanism of SIRT1 activation by a 1,4-dihydropyridine.Journal of molecular modeling · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many 1,4-dihydropyridines (DHPs) possess redox properties. In this review DHPs are surveyed as protectors against oxidative stress (OS) and related disorders, considering the DHPs as specific group of potential antioxidants with bioprotective capacities. They have several peculiarities related to antioxidant activity (AOA). Several commercially available calcium antagonist, 1,4-DHP drugs, their metabolites, and calcium agonists were shown to express AOA. Synthesis, hydrogen donor properties, AOA, and methods and approaches used to reveal biological activities of various groups of 1,4-DHPs are presented. Examples of DHPs antioxidant activities and protective effects of DHPs against OS induced damage in low density lipoproteins (LDL), mitochondria, microsomes, isolated cells, and cell cultures are highlighted. Comparison of the AOA of different DHPs and other antioxidants is also given. According to the data presented, the DHPs might be considered as bellwether among synthetic compounds targeting OS and potential pharmacological model compounds targeting oxidative stress important for medicinal chemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.