ArticleJournal of immunology (Baltimore, Md. : 1950)2016
T-bet Regulates Natural Regulatory T Cell Afferent Lymphatic Migration and Suppressive Function.
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Regulatory T cell and endothelial cell crosstalk.Nature reviews. Immunology · 2025Review
- Regulatory T cell dysfunction and immunotherapeutic breakthroughs in type 1 diabetes.Frontiers in endocrinology · 2025Review
- Article
- Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses.Cell reports · 2022Article
- Imaging leukocyte migration through afferent lymphatics.Immunological reviews · 2022Review
- T helper cell trafficking in autoimmune kidney diseases.Cell and tissue research · 2021Review
- The role of Treg subtypes in glomerulonephritis.Cell and tissue research · 2021Review
- Review
- Review
- Type 1 TNature immunology · 2020Article
- A wave of Foxp3Cellular & molecular immunology · 2020Article
- Technical Considerations in Ex Vivo Human Regulatory T Cell Migration and Suppression Assays.Cells · 2020Review
- CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration.Science immunology · 2019Article
- Article
- CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production.Cell death & disease · 2018Article
- Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling.Nature communications · 2018Article
- Harnessing the lymph node microenvironment.Current opinion in organ transplantation · 2018Review
- A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation.Frontiers in immunology · 2018Article
- Bioimaging of alloantigen-stimulated regulatory T cells in rat vascularized composite allotransplantation.PloS one · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
T-bet is essential for natural regulatory T cells (nTreg) to regulate Th1 inflammation, but whether T-bet controls other Treg functions after entering the inflammatory site is unknown. In an islet allograft model, T-bet(-/-) nTreg, but not induced Treg, failed to prolong graft survival as effectively as wild-type Treg. T-bet(-/-) nTreg had no functional deficiency in vitro but failed to home from the graft to draining lymph nodes (dLN) as efficiently as wild type. T-bet regulated expression of adhesion- and migration-related molecules, influencing nTreg distribution in tissues, so that T-bet(-/-) nTreg remained in the grafts rather than migrating to lymphatics and dLN. In contrast, both wild-type and T-bet(-/-) CD4(+) conventional T cells and induced Treg migrated normally toward afferent lymphatics. T-bet(-/-) nTreg displayed instability in the graft, failing to suppress Ag-specific CD4(+) T cells and prevent their infiltration into the graft and dLN. Thus, T-bet regulates nTreg migration into afferent lymphatics and dLN and consequently their suppressive stability in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.