Evidence map›Paper›PMID 26880625›Full record

ArticleMedical hypotheses2016

Electrical stimulation to optimize cardioprotective exosomes from cardiac stem cells.

C R Campbell, A E Berman, N L Weintraub, Y L Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical hypotheses, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

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  15. Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes for Angiogenesis.Journal of cardiovascular translational research · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

C R CampbellVascular Biology Center, Department of Medicine, Medical College of Georgia/Georgia Regents University, 1459 Laney Walker Boulevard, Augusta, GA 30912, United States.
A E BermanVascular Biology Center, Department of Medicine, Medical College of Georgia/Georgia Regents University, 1459 Laney Walker Boulevard, Augusta, GA 30912, United States.
N L WeintraubVascular Biology Center, Department of Medicine, Medical College of Georgia/Georgia Regents University, 1459 Laney Walker Boulevard, Augusta, GA 30912, United States.
Y L TangVascular Biology Center, Department of Medicine, Medical College of Georgia/Georgia Regents University, 1459 Laney Walker Boulevard, Augusta, GA 30912, United States. Electronic address: yaotang@gru.edu.
Augusta University · US

Funding

Vascular Protection During HypertensionP01HL062984 · NHLBI · UNIVERSITY OF IOWA · PI FARACI, FRANK M · 2000 to 2015
$22.2M
Hypoxia and cardiac stem cell homingR01HL086555 · NHLBI · UNIVERSITY OF CINCINNATI · PI TANG, YAO LIANG · 2008 to 2019
$3.5M
Angiotensin II, oxidative stress, and aneurysm formationR01HL076684 · NHLBI · UNIVERSITY OF IOWA · PI WEINTRAUB, NEAL L · 2005 to 2013
$3.0M
Perivascular adipose tissue and vascular remodelingR01HL112640 · NHLBI · UNIVERSITY OF CINCINNATI · PI WEINTRAUB, NEAL L · 2012 to 2016
$2.1M
NHLBI NIH HHS HL076684NHLBI NIH HHS HL086555NHLBI NIH HHS HL62984NHLBI NIH HHS P01 HL062984NHLBI NIH HHS R01 HL076684NHLBI NIH HHS R01 HL086555NHLBI NIH HHS R01 HL112640
6 · The paper itself

Abstract

Injured or ischemic cardiac tissue has limited intrinsic capacity for regeneration. While stem cell transplantation is a promising approach to stimulating cardiac repair, its success in humans has thus far been limited. Harnessing the therapeutic benefits of stem cells requires a better understanding of their mechanisms of action and methods to optimize their function. Cardiac stem cells (CSC) represent a particularly effective cellular source for cardiac repair, and pre-conditioning CSC with electrical stimulation (EleS) was demonstrated to further enhance their function, although the mechanisms are unknown. Recent studies suggest that transplanted stem cells primarily exert their effects through communicating with endogenous tissues via the release of exosomes containing cardioprotective molecules such as miRNAs, which upon uptake by recipient cells may stimulate survival, proliferation, and angiogenesis. Exosomes are also effective therapeutic agents in isolation and may provide a feasible alternative to stem cell transplantation. We hypothesize that EleS enhances CSC-mediated cardiac repair through its beneficial effects on production of cardioprotective exosomes. Moreover, we hypothesize that the beneficial effects of biventricular pacing in patients with heart failure may in part result from EleS-induced preconditioning of endogenous CSC to promote cardiac repair. With future research, our hypothesis may provide applications to optimize stem cell therapy and augment current pacing protocols, which may significantly advance the treatment of patients with heart disease.

Indexed as

Electric StimulationCell SurvivalExosomesHeartHeart FailureHumansMicroRNAsModels, TheoreticalPacemaker, ArtificialRegenerationStem CellsStem Cell TransplantationMicroRNAs

Identifiers

PMID26880625
PMCPMC4757848
OpenAlexW2237802870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.