ArticleeLife2016
Bitter taste receptors confer diverse functions to neurons.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 73 citations in OpenAlex.
- A bitter receptor links chemical detection to adaptive foraging avoidance in fire ants.Pest management science · 2026Article
- A Molecular and Cellular Mechanism for Bitter Taste in the mosquitobioRxiv : the preprint server for biology · 2026Article
- CaRPOOL: a pooled calcium‑recording CRISPR screening platform identifies CCR7 as a modulator of cellular osmomechanosensing.Cell communication and signaling : CCS · 2026Article
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Molecular evolution of gustatory receptors in the Anopheles gambiae complex.BMC ecology and evolution · 2025Article
- Opponent coding mechanisms in Drosophila taste neurons.Chemical senses · 2025Review
- Food hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology.PLoS biology · 2025Article
- Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024Review
- Antennal Transcriptome Screening and Identification of Chemosensory Proteins in the Double-Spine European Spruce Bark Beetle,International journal of molecular sciences · 2024Article
- The larva and adult ofeLife · 2024Article
- Base Recording: A Technique for Analyzing Responses of Taste Neurons in Drosophila.Journal of visualized experiments : JoVE · 2024Article
- Larval microbiota primes the Drosophila adult gustatory response.Nature communications · 2024Article
- Mechanisms of gas sensing by internal sensory neurons inbioRxiv : the preprint server for biology · 2024Article
- Identification of candidate chemosensory genes inFrontiers in physiology · 2024Article
- Comparative transcriptome analysis of the antenna and proboscis reveals feeding state-dependent chemosensory genes inOpen biology · 2024Article
- Diverse mechanisms of taste coding inScience advances · 2023Article
- Taste coding of heavy metal ion-induced avoidance iniScience · 2023Article
- Interactions between Beer Compounds and Human Salivary Proteins: Insights toward Astringency and Bitterness Perception.Molecules (Basel, Switzerland) · 2023Article
- Taste adaptations associated with host specialization in the specialist Drosophila sechellia.The Journal of experimental biology · 2023Article
- The chemosensory system of theFly · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bitter compounds elicit an aversive response. In Drosophila, bitter-sensitive taste neurons coexpress many members of the Gr family of taste receptors. However, the molecular logic of bitter signaling is unknown. We used an in vivo expression approach to analyze the logic of bitter taste signaling. Ectopic or overexpression of bitter Grs increased endogenous responses or conferred novel responses. Surprisingly, expression of Grs also suppressed many endogenous bitter responses. Conversely, deletion of an endogenous Gr led to novel responses. Expression of individual Grs conferred strikingly different effects in different neurons. The results support a model in which bitter Grs interact, exhibiting competition, inhibition, or activation. The results have broad implications for the problem of how taste systems evolve to detect new environmental dangers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.