ArticleeLife2016
Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Patterns of Gray Matter Abnormalities in Idiopathic Generalized Epilepsy: A Meta-Analysis of Voxel-Based Morphology Studies.PloS one · 2017Pooled it
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- Role of gamma-aminobutyric acid-ergic neurons in the thalamic reticular nucleus in regulating sleep-wake cycles in mice treated with acupuncture for insomnia.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Sleep Slow-Wave and Spindle Alterations in Young Smokers Correlated With the Severity of Cigarette Exposure.Addiction biology · 2026Article
- The Informational Blackout chronic pain and fatigue as rational outputs of a brain operating on degraded biological signals.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Parvalbumin and Somatostatin Neurons in the Thalamic Reticular Nucleus Modulate Visual Information Processing in V1 of Mouse.Neuroscience bulletin · 2025Article
- Review
- Visual hallucinations in Parkinson's disease: spotlight on central cholinergic dysfunction.Brain : a journal of neurology · 2025Review
- Article
- Abnormal power and spindle wave activity during sleep in young smokers.Frontiers in neuroscience · 2025Article
- Article
- The Mesencephalic Locomotor Region: Multiple Cell Types, Multiple Behavioral Roles, and Multiple Implications for Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns.Cell reports · 2024Article
- Functionally Distinct Circuits Are Linked by Heterocellular Electrical Synapses in the Thalamic Reticular Nucleus.eNeuro · 2024Article
- Propofol modulates neural dynamics of thalamo-cortical system associated with anesthetic levels in rats.Cognitive neurodynamics · 2023Article
- Facilitation of Behavioral and Cortical Emergence from Isoflurane Anesthesia by GABAergic Neurons in Basal Forebrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuro-orchestration of sleep and wakefulness.Nature neuroscience · 2023Review
- Arousal Regulation by the External Globus Pallidus: A New Node for the Mesocircuit Hypothesis.Brain sciences · 2023Article
- Understanding Sleep Regulation in Normal and Pathological Conditions, and Why It Matters.Journal of Huntington's disease · 2023Review
- Roles of Neuropeptides in Sleep-Wake Regulation.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Cholinergic projections from the basal forebrain and brainstem are thought to play important roles in rapid eye movement (REM) sleep and arousal. Using transgenic mice in which channelrhdopsin-2 is selectively expressed in cholinergic neurons, we show that optical stimulation of cholinergic inputs to the thalamic reticular nucleus (TRN) activates local GABAergic neurons to promote sleep and protect non-rapid eye movement (NREM) sleep. It does not affect REM sleep. Instead, direct activation of cholinergic input to the TRN shortens the time to sleep onset and generates spindle oscillations that correlate with NREM sleep. It does so by evoking excitatory postsynaptic currents via α7-containing nicotinic acetylcholine receptors and inducing bursts of action potentials in local GABAergic neurons. These findings stand in sharp contrast to previous reports of cholinergic activity driving arousal. Our results provide new insight into the mechanisms controlling sleep.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.