ArticleeLife2016
A synergy-based hand control is encoded in human motor cortical areas.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07077460 (Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback), which is not on this map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Object-oriented hand dexterity and grasping abilities, from the animal quarters to the neurosurgical OR: a systematic review of the underlying neural correlates in non-human, human primate and recent findings in awake brain surgery.Frontiers in integrative neuroscience · 2024Pooled it
- Exploring representations of human grasping in neural, muscle and kinematic signals.Scientific reports · 2018Trial
- Superficial Ventral Premotor Pathways to Primary Motor Cortex Shape the Temporal Coordination of Precision Graspinnog.The European journal of neuroscience · 2026Article
- Design, development, and validation of a multimodal synergy-based intuitive virtual and augmented reality therapy platform for mental health.Frontiers in robotics and AI · 2026Article
- Spontaneously emerging patterns in human motor cortex code for somatotopic specific movements.iScience · 2025Article
- Reconstructing hand gestures with synergies extracted from dance movements.Scientific reports · 2025Article
- Decoding multi-joint hand movements from brain signals by learning a synergy-based neural manifold.Patterns (New York, N.Y.) · 2025Article
- Functional organization of the primary motor cortex in psychosis and the potential role of intereffector regions in psychomotor slowing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Test-Retest Reliability of a Computerized Hand-Eye Coordination Task.Journal of eye movement research · 2025Article
- Object-directed action representations are componentially built in parietal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Action-type mapping principles extend beyond evolutionarily conserved actions, even in people born without hands.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Highly Efficient HMI Algorithm for Controlling a Multi-Degree-of-Freedom Prosthetic Hand Using Sonomyography.Sensors (Basel, Switzerland) · 2025Article
- Next-Generation Neurotechnologies Inspired by Motor Primitive Model for Restoring Human Natural Movement.Research (Washington, D.C.) · 2025Review
- Motor actions across psychiatric disorders: A research domain criteria (RDoC) perspective.Clinical psychology review · 2024Review
- Human motor learning dynamics in high-dimensional tasks.PLoS computational biology · 2024Article
- Article
- Investigation of adaptive muscle synergy modulated motor responses to grasping perturbations.Scientific reports · 2024Article
- Robust discrimination of multiple naturalistic same-hand movements from MEG signals with convolutional neural networks.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Comparison of synergy patterns between the right and left hand while performing postures and object grasps.Scientific reports · 2023Article
- Spontaneous activity patterns in human motor cortex replay evoked activity patterns for hand movements.Scientific reports · 2022Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How the human brain controls hand movements to carry out different tasks is still debated. The concept of synergy has been proposed to indicate functional modules that may simplify the control of hand postures by simultaneously recruiting sets of muscles and joints. However, whether and to what extent synergic hand postures are encoded as such at a cortical level remains unknown. Here, we combined kinematic, electromyography, and brain activity measures obtained by functional magnetic resonance imaging while subjects performed a variety of movements towards virtual objects. Hand postural information, encoded through kinematic synergies, were represented in cortical areas devoted to hand motor control and successfully discriminated individual grasping movements, significantly outperforming alternative somatotopic or muscle-based models. Importantly, hand postural synergies were predicted by neural activation patterns within primary motor cortex. These findings support a novel cortical organization for hand movement control and open potential applications for brain-computer interfaces and neuroprostheses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.