SynthesisEuropean child & adolescent psychiatry2016
The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review.
Synthesis in European child & adolescent psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Open Trial of Median Nerve Stimulation for Treatment of Tourette Syndrome
Finalizing and Testing an Online Therapist Training and Assistance Program to Facilitate Implementation of Comprehensive Behavioral Intervention for Tic Disorders
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Relaxation therapy as a treatment for tics in patients with Tourette syndrome: a systematic literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- Safety of aripiprazole for tics in children and adolescents: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Therapist-guided, mobile app-assisted behavioural treatment for children and adolescents with chronic tic disorders: a pilot randomised controlled trial.European child & adolescent psychiatry · 2026Trial
- Safety and Effect of 12-Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome.Movement disorders clinical practice · 2025Trial
- Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study.Pharmacopsychiatry · 2022Trial
- Effect of behavior therapy for Tourette's disorder on psychiatric symptoms and functioning in adults.Psychological medicine · 2020Trial
- Combined habit reversal training and exposure response prevention in a group setting compared to individual training: a randomized controlled clinical trial.European child & adolescent psychiatry · 2019Trial
- From cradle to Tic: early developmental profiles of tourette syndrome and its comorbidities in the MoBa cohort.European child & adolescent psychiatry · 2026Article
- Lessons learned from including Patient and Public Involvement members throughout research projects in Tic Disorder research.Research involvement and engagement · 2026Article
- Psychiatric Comorbidity, Tic Severity and Quality of Life in Adults with Tourette's Syndrome.Movement disorders clinical practice · 2026Article
- Digital-Supported Delivery of Behavioural Therapy for Patients with Tic Disorders: A Narrative Review.Brain sciences · 2026Review
- Remote delivery of a mindfulness-based intervention for adults with tics: Protocol of a randomized controlled trial.Contemporary clinical trials · 2026Article
- Experiences of self-identification, diagnosis and support for adults seeking a recognition of tic disorders in the United Kingdom.Primary health care research & development · 2026Article
- The Effect of Uridine Diphosphate-Glucuronosyltransferase Inhibition on the Pharmacokinetics of Ecopipam and Its Metabolites.Clinical and translational science · 2026Article
- The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications.Clinical and translational science · 2026Article
- Treatment non-persistence in children and adolescents with Tourette syndrome newly treated with dopamine D2 receptor modulators.Frontiers in psychiatry · 2026Article
- Clinical Features, Mechanisms, and Management of Anxiety in Youth with Tic Disorders: A Narrative Review.Neuropsychiatric disease and treatment · 2026Review
- Protocol for developing an evidence-based expert consensus on efficacy evaluation and comorbidity management of integrated Chinese and Western medicine for pediatric tic disorders: a GRADE-based modified Delphi study.Frontiers in neurology · 2026Article
- The Association of Quality of Life with Psychosocial Factors in Adolescents with Tourette Syndrome.Child psychiatry and human development · 2025Article
- Exploring Empowerment in Online Support Communities for People Living With Tic Disorders and Tourette Syndrome: Qualitative Survey Study of User Experiences.JMIR formative research · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gilles de la Tourette syndrome (GTS) and other chronic tic disorders are neurodevelopmental conditions characterized by the presence of tics and associated behavioral problems. Whilst converging evidence indicates that these conditions can affect patients' quality of life (QoL), the extent of this impairment across the lifespan is not well understood. We conducted a systematic literature review of published QoL studies in GTS and other chronic tic disorders to comprehensively assess the effects of these conditions on QoL in different age groups. We found that QoL can be perceived differently by child and adult patients, especially with regard to the reciprocal contributions of tics and behavioral problems to the different domains of QoL. Specifically, QoL profiles in children often reflect the impact of co-morbid attention-deficit and hyperactivity symptoms, which tend to improve with age, whereas adults' perception of QoL seems to be more strongly affected by the presence of depression and anxiety. Management strategies should take into account differences in age-related QoL needs between children and adults with GTS or other chronic tic disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.