ArticleBMC ophthalmology2016
The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of autoimmune and infectious diseases.
Article in BMC ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02627209 (Non-infectious and Infectious Uveitis Diagnosis), which is not on this map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-infectious and Infectious Uveitis Diagnosis
Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Assessing the Combined Diagnostic Value of Serum ACE Levels, Mantoux Test and Lymphopenia in Uveitis Patients from a Tertiary Eye Care Center in Southern India.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- [Non-infectious anterior uveitis : S1 guideline of the German Society of Ophthalmology (DOG) and the German Professional Association of Ophthalmologists (BVA). Version: 13.12.2023].Die Ophthalmologie · 2025Review
- A Comparison Study of Lymph Node Tuberculosis and Sarcoidosis Involvement to Facilitate Differential Diagnosis and to Establish a Predictive Score for Tuberculosis.Pathogens (Basel, Switzerland) · 2024Article
- Effects of prebiotic (lactoferrin) and diclazuril on broiler chickens experimentally infected withFrontiers in veterinary science · 2024Article
- Lysozyme-induced nephropathy due to systemic granulomatous disease.Clinical case reports · 2023Article
- Diagnostic efficacy of elevated serum angiotensin-converting enzyme and lymphopenia between presumed sarcoid uveitis and presumed tubercular uveitis.International ophthalmology · 2023Article
- Sarcoidosis-Related Uveitis: A Review.Journal of clinical medicine · 2023Review
- Sarcoid Uveitis: An Intriguing Challenger.Medicina (Kaunas, Lithuania) · 2022Review
- Article
- Diagnostic value of lymphopaenia and elevated serum ACE in patients with uveitis.The British journal of ophthalmology · 2021Article
- Effects of the prebiotic lactoferrin on multidrug-resistantVeterinary world · 2021Article
- The Comparative Value of Serum Angiotensin Converting Enzyme (ACE) and Lysozyme and the Use of Polyclonal Antibody Activation in the Work-up of Ocular Sarcoidosis.Diagnostics (Basel, Switzerland) · 2021Article
- Uveitis as an Open Window to Systemic Inflammatory Diseases.Journal of clinical medicine · 2021Article
- Development of a random forest model to classify sarcoidosis and tuberculosis.American journal of translational research · 2021Article
- Article
- Immobilization Techniques for Aptamers on Gold Electrodes for the Electrochemical Detection of Proteins: A Review.Biosensors · 2020Review
- Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments.Journal of clinical medicine · 2020Review
- The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-ResistantAntimicrobial agents and chemotherapy · 2019Article
- Ocular sarcoidosis: new diagnostic modalities and treatment.Current opinion in pulmonary medicine · 2017Review
- Endogenous antimicrobial factors in the treatment of infectious diseases.Central-European journal of immunology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased serum levels of angiotensin converting enzyme and lysozyme are considered as inflammatory markers for diagnosis of sarcoidosis which is an autoimmune inflammatory disease. The purpose of this study is to evaluate the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
methodsThis is a prospective study involving patients with ankylosing spondylitis, behcet's disease, presumed sarcoidosis, presumed latent tuberculosis, presumed latent syphilis, and control group. The serum levels of angiotensin converting enzyme and lysozyme were analyzed by enzyme-linked immunosorbent assay. Bonnferoni analysis was used to assess pairwise comparisons between the groups.
resultsThere was a significant increase in serum angiotensin converting enzyme level in patients with presumed sarcoidosis compared to ankylosing spondylitis (p = 0.0001), behcet's disease (p = 0.0001), presumed latent tuberculosis (p = 0.0001), presumed latent syphilis (p = 0.0001), and control group (p = 0.0001). The increase in serum lysozyme level was significant for patients with presumed sarcoidosis with respect to ankylosing spondylitis (p = 0.0001), behcet's disease, (p = 0.0001) presumed latent tuberculosis (p = 0.001), presumed latent syphilis (p = 0.033), and control group (p = 0.0001).
conclusionElevated serum angiotensin converting enzyme levels are significant for patients with presumed sarcoidosis compared to ocular involvement of other autoimmune diseases such as behcet's disease and ankylosing spondylitis, and ocular involvement of infectious diseases such as presumed latent tuberculosis and presumed latent syphilis. However, elevated serum lysozyme level might be also detected in ocular involvement of infectious diseases such as presumed latent tuberculosis and presumed latent syphilis.
trial registrationTRIAL REGISTRATION NUMBER: NCT02627209. Date of registration: 12/09/2015.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.