ArticleMalaria journal2016
Timing of malaria in pregnancy and impact on infant growth and morbidity: a cohort study in Uganda.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00495508 (A Randomised, Open-label Non-inferiority Trial of Artemether-lumefantrine Versus Quinine for the Treatment of Uncomplicated Falciparum Malaria During Pregnancy, Mbarara, Uganda), which is not on this map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised, Open-label Non-inferiority Trial of Artemether-lumefantrine Versus Quinine for the Treatment of Uncomplicated Falciparum Malaria During Pregnancy, Mbarara, Uganda (2006-2007)
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Impact of Malaria in Pregnancy on Risk of Malaria in Young Children: Systematic Review and Meta-Analyses.The Journal of infectious diseases · 2020Pooled it
- Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review.Malaria journal · 2019Pooled it
- Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review.Malaria journal · 2017Pooled it
- Infant sex modifies associations between placental malaria and risk of malaria in infancy.Malaria journal · 2020Trial
- Zika virus infection in pregnancy and infant growth, body composition in the first three months of life: a cohort study.Scientific reports · 2019Trial
- Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study.PLoS medicine · 2019Trial
- Impact of Microscopic and Submicroscopic Parasitemia During Pregnancy on Placental Malaria in a High-Transmission Setting in Uganda.The Journal of infectious diseases · 2019Trial
- Association between placental malaria, postnatal linear growth, and body mass index in the Dogon Longitudinal Study, Mali.Malaria journal · 2026Article
- Trimester of maternal SARS-CoV-2 infection differentially predicts newborn size in the COVID-19 Mother Baby Outcomes (COMBO) cohort.Pediatric research · 2026Article
- Determinants of the optimal uptake of sulfadoxine-pyrimethamine doses for intermittent treatment of malaria in pregnancy in urban Nigeria.Scientific reports · 2024Article
- Pathways through which intermittent preventive treatment for malaria in pregnancy influences child growth faltering: a mediation analysis.medRxiv : the preprint server for health sciences · 2024Article
- Predictors of birth weight in pregnant women with malaria: a prospective cohort facility-based study in Webuye-Kenya.BMC pregnancy and childbirth · 2024Article
- Mosquito bed net use and associated factors among pregnant women in Rwanda: a nationwide survey.BMC pregnancy and childbirth · 2023Article
- Malaria reduction drives childhood stunting decline in Uganda: a mixed-methods country case study.The American journal of clinical nutrition · 2022Article
- Immune Regulation, Maternal Infection, Vaccination, and Pregnancy Outcome.Journal of women's health (2002) · 2021Article
- The immune response to malaria in utero.Immunological reviews · 2020Review
- Article
- Ex vivo efficacy of selective chalcone derivatives on reference strains and field isolates ofPathogens and global health · 2019Article
- An overview of malaria in pregnancy.Seminars in perinatology · 2019Review
- Genesis of placental sequestration in malaria and possible targets for drugs for placental malaria.Birth defects research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalaria in pregnancy (MiP) is a major cause of fetal growth restriction and low birth weight in endemic areas of sub-Saharan Africa. Understanding of the impact of MiP on infant growth and infant risk of malaria or morbidity is poorly characterized. The objective of this study was to describe the impact of MIP on subsequent infant growth, malaria and morbidity.
methodsBetween 2006 and 2009, 82 % (832/1018) of pregnant women with live-born singletons and ultrasound determined gestational age were enrolled in a prospective cohort with active weekly screening and treatment for malaria. Infants were followed monthly for growth and morbidity and received active monthly screening and treatment for malaria during their first year of life. Multivariate analyses were performed to analyse the association between malaria exposure during pregnancy and infants' growth, malaria infections, diarrhoea episodes and acute respiratory infections.
resultsMedian time of infant follow-up was 12 months and infants born to a mother who had MiP were at increased risk of impaired height and weight gain (-2.71 cm, 95 % CI -4.17 to -1.25 and -0.42 kg, 95 % CI -0.76 to -0.08 at 12 months for >1 MiP compared to no MiP) and of malaria infection (relative risk 10.42, 95 % CI 2.64-41.10 for infants born to mothers with placental malaria). The risks of infant growth restriction and infant malaria infection were maximal when maternal malaria occurred in the 12 weeks prior to delivery. Recurrent MiP was also associated with acute respiratory infection (RR 1.96, 95 % CI 1.25-3.06) and diarrhoea during infancy (RR 1.93, 95 % CI 1.02-3.66).
conclusionThis study shows that despite frequent active screening and prompt treatment of MiP, impaired growth and an increased risk of malaria and non-malaria infections can be observed in the infants. Effective preventive measures in pregnancy remain a research priority. This study was registered with ClinicalTrials.gov, number NCT00495508.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.