Evidence map›Paper›PMID 26879600›Full record

ReviewThe British journal of nutrition2016

Could gestational diabetes mellitus be managed through dietary bioactive compounds? Current knowledge and future perspectives.

Carmela Santangelo, Alessandra Zicari, Elisabetta Mandosi, Beatrice Scazzocchio, Emanuela Mari, Susanna Morano, Roberta Masella

Open access · hybridAbstract readReview
In one paragraph

Review in The British journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  16. Article
  17. Epigenetic Changes in Gestational Diabetes Mellitus.International journal of molecular sciences · 2021
    Review
  18. Article
  19. Adiponectin as a Potential Biomarker for Pregnancy Disorders.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carmela Santangelo1Department of Veterinary Public Health and Food Safety,Unit of Nutrition,Italian National Institute of Health,Viale Regina Elena 299,00161 Rome,Italy.
Alessandra Zicari2Department of Experimental Medicine,2nd Section of Cell Pathology,Sapienza University of Rome,Viale Regina Elena 324,00161 Rome,Italy.
Elisabetta Mandosi3Department of Experimental Medicine,Section of Medical Pathophysiology, Food Science and Endocrinology,Sapienza University of Rome,Viale Regina Elena 324,00161 Rome,Italy.
Beatrice Scazzocchio1Department of Veterinary Public Health and Food Safety,Unit of Nutrition,Italian National Institute of Health,Viale Regina Elena 299,00161 Rome,Italy.
Emanuela Mari2Department of Experimental Medicine,2nd Section of Cell Pathology,Sapienza University of Rome,Viale Regina Elena 324,00161 Rome,Italy.
Susanna Morano3Department of Experimental Medicine,Section of Medical Pathophysiology, Food Science and Endocrinology,Sapienza University of Rome,Viale Regina Elena 324,00161 Rome,Italy.
Roberta Masella1Department of Veterinary Public Health and Food Safety,Unit of Nutrition,Italian National Institute of Health,Viale Regina Elena 299,00161 Rome,Italy.
Sapienza University of Rome · ITIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is a serious problem growing worldwide that needs to be addressed with urgency in consideration of the resulting severe complications for both mother and fetus. Growing evidence indicates that a healthy diet rich in fruit, vegetables, nuts, extra-virgin olive oil and fish has beneficial effects in both the prevention and management of several human diseases and metabolic disorders. In this review, we discuss the latest data concerning the effects of dietary bioactive compounds such as polyphenols and PUFA on the molecular mechanisms regulating glucose homoeostasis. Several studies, mostly based on in vitro and animal models, indicate that dietary polyphenols, mainly flavonoids, positively modulate the insulin signalling pathway by attenuating hyperglycaemia and insulin resistance, reducing inflammatory adipokines, and modifying microRNA (miRNA) profiles. Very few data about the influence of dietary exposure on GDM outcomes are available, although this approach deserves careful consideration. Further investigation, which includes exploring the 'omics' world, is needed to better understand the complex interaction between dietary compounds and GDM.

Indexed as

DietAdipokinesAnimalsBlood GlucoseDiabetes, GestationalFatty Acids, UnsaturatedFemaleFlavonoidsFruitHomeostasisHumansInsulinInsulin ResistanceMicroRNAsPolyphenolsPregnancyAdipokinesBlood GlucoseFatty Acids, UnsaturatedFlavonoidsInsulinMicroRNAsPolyphenolsAdipokinesAkt protein kinase BALA α-linolenic acidAMPK AMP-activated protein kinaseAT adipose tissueC3G cyanidin-3-glucosideDietary polyphenolsEGCG epigallocatechin gallateFABP FA-binding proteinFA fatty acidsGDM gestational diabetes mellitusGestational diabetes mellitusIR insulin resistanceIRS-1 insulin receptor substrate 1LA linoleic acidLC-PUFA long-chain PUFAMedDiet Mediterranean-style dietMediterranean dietMicroRNAmiRNA microRNAMolecular mechanismsPUFARSV resveratrolT2D type 2 diabetes

Identifiers

PMID26879600
PMCPMC4825102
OpenAlexW2284707940

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.