Evidence map›Paper›PMID 26879545›Full record

Trial reportGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2017

Feasibility of weekly intraperitoneal versus intravenous paclitaxel therapy delivered from the day of radical surgery for gastric cancer: a preliminary safety analysis of the INPACT study, a randomized controlled trial.

Yasuhiro Kodera, Naoto Takahashi, Takaki Yoshikawa, Nobuhiro Takiguchi, Kazumasa Fujitani, Yuichi Ito, Katsufumi Miyamoto, Osamu Takayama, Motohiro Imano, Daisuke Kobayashi and 3 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
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  3. Article
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  6. Intraperitoneal chemotherapy for gastric cancer with peritoneal metastasis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 1 country.

Yasuhiro KoderaDepartment of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan. ykodera@med.nagoya-u.ac.jp.
Naoto TakahashiDepartment of Surgery, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan.
Takaki YoshikawaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Nobuhiro TakiguchiDivision of Gastroenterological Surgery, Chiba Cancer Center, Chiba, Japan.
Kazumasa FujitaniDepartment of Surgery, Osaka General Medical Center, Osaka, Japan.
Yuichi ItoDepartment of Gastroenterological Surgery, Aichi Cancer Center, Nagoya, Japan.
Katsufumi MiyamotoDepartment of Surgery, Hyogo Prefectural Awaji Medical Center, Sumoto, Japan.
Osamu TakayamaDepartment of Surgery, Itami City Hospital, Itami, Japan.
Motohiro ImanoDepartment of Surgery, Faculty of Medicine, Kinki University, Higashiosaka, Japan.
Daisuke KobayashiDepartment of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan.
Yumi MiyashitaData Center, Epidemiological and Clinical Research Information Network, Kyoto, Japan.
Satoshi MoritaDepartment of Biomedical Statistics and Bioinformatics, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Junichi SakamotoTokai Central Hospital, Kakamigahara, Japan.
Nagoya University · JPAichi Cancer Center · JPChiba Cancer Center · JPHyogo Prefectural Awaji Medical Center · JPItami City Hospital · JPJikei University Kashiwa hospital · JPKanagawa Prefectural Hospital Organization · JPKindai University · JPKyoto University · JPOsaka Prefectural Medical Center · JPTokai Central Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeritoneal carcinomatosis is common after curative resection of gastric cancer. Intraperitoneal administration of paclitaxel (PTX) is known to control ovarian peritoneal metastases. PATIENTS AND

methodsPatients with either linitis plastica or T4 cancer with high risk of peritoneal metastasis or recurrence but whose cancer was considered resectable were preregistered. After their cancer had been confirmed intraoperatively as resectable, the patients were randomized into either group A (PTX at 60 mg/m

resultsOf 177 preregistered patients, 83 underwent treatment (39 by intraperitoneal administration and 44 by intravenous administration). There was no difference in patient demographics between the two groups. The incidences of surgical complications were similar between the groups, except for transient bowel obstruction observed exclusively in group A. The relative dose intensity of PTX was 81.4 % for group A and 76.3 % for group B. There was one death due to pulmonary thrombosis and a case of anaphylaxis that led to termination of the protocol treatment (group B). Other adverse events were mild and manageable.

conclusionsIntraperitoneal administration of PTX from the day of gastrectomy did not result in a higher incidence of surgical complications and adverse reactions when compared with intravenous administration of PTX.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsDrug CombinationsFeasibility StudiesFemaleFollow-Up StudiesGastrectomyHumansInjections, IntraperitonealLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessDrug CombinationsOxonic AcidPaclitaxelS 1 (combination)TegafurGastric cancerIntraperitoneal administrationPaclitaxelPeritoneal carcinomatosis

Identifiers

PMID26879545
OpenAlexW2279109387

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.