ArticleScientific reports2016
Whole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 116 citations in OpenAlex.
- Potential drivers for schistosomiasis persistence: Population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands.PLoS neglected tropical diseases · 2022Trial
- Population genomics reveals multi-scale mechanisms sustaining schistosomiasis re-emergence in a near-elimination setting.PLoS neglected tropical diseases · 2026Article
- Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemicScience advances · 2026Article
- Haplotype-resolved genome ofZoological research · 2026Article
- Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Zoonotic Schistosomiasis: The Crossroads Between Animal and Human Schistosomiasis in Africa: Narrative Review.Health science reports · 2025Article
- Schistosome exposure and diet induced effects on candidate immune gene expression in an African snail vector.Journal of helminthology · 2025Article
- Genetic analysis of Schistosoma mansoni in a low-transmission area in Brazil suggests population sharing between wild-hosts and humans and geographical isolation.PLoS neglected tropical diseases · 2025Article
- The Senegalese and Brazilian strains of Schistosoma mansoni exhibit high compatibility with Biomphalaria pfeifferi and Biomphalaria glabrata.Parasites & vectors · 2025Article
- Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets.Nature communications · 2025Article
- Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment.Nature communications · 2025Article
- Schistosome exposure and diet induced effects on candidate immune gene expression in an African snail vector.bioRxiv : the preprint server for biology · 2025Article
- The research contribution of the Schistosomiasis Collection at the Natural History Museum (SCAN): highlights, challenges and future directions.Infectious diseases of poverty · 2025Review
- Paleoparasitological analysis of a 15th-16th c. CE latrine from the merchant quarter of Bruges, Belgium: Evidence for local and exotic parasite infections.Parasitology · 2024Article
- Hybrid-Capture Target Enrichment in Human Pathogens: Identification, Evolution, Biosurveillance, and Genomic Epidemiology.Pathogens (Basel, Switzerland) · 2024Review
- Chromosome-scale genome of the human blood fluke Schistosoma mekongi and its implications for public health.Infectious diseases of poverty · 2023Article
- Reaching the World Health Organization elimination targets for schistosomiasis: the importance of a One Health perspective.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Integrating genomic and epidemiologic data to accelerate progress toward schistosomiasis elimination.eLife · 2022Review
- Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities.PLoS neglected tropical diseases · 2022Article
- Phylogenomics and Diversification of the Schistosomatidae Based on Targeted Sequence Capture of Ultra-Conserved Elements.Pathogens (Basel, Switzerland) · 2022Article
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Authors and funding
12 authors at 4 institutions in 1 country.
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Abstract
Schistosoma mansoni is a parasitic fluke that infects millions of people in the developing world. This study presents the first application of population genomics to S. mansoni based on high-coverage resequencing data from 10 global isolates and an isolate of the closely-related Schistosoma rodhaini, which infects rodents. Using population genetic tests, we document genes under directional and balancing selection in S. mansoni that may facilitate adaptation to the human host. Coalescence modeling reveals the speciation of S. mansoni and S. rodhaini as 107.5-147.6KYA, a period which overlaps with the earliest archaeological evidence for fishing in Africa. Our results indicate that S. mansoni originated in East Africa and experienced a decline in effective population size 20-90KYA, before dispersing across the continent during the Holocene. In addition, we find strong evidence that S. mansoni migrated to the New World with the 16-19th Century Atlantic Slave Trade.
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