Evidence map›Paper›PMID 26879294›Full record

Trial reportAesthetic surgery journal2016

Expanded Stem Cells, Stromal-Vascular Fraction, and Platelet-Rich Plasma Enriched Fat: Comparing Results of Different Facial Rejuvenation Approaches in a Clinical Trial.

Gino Rigotti, Luiz Charles-de-Sá, Natale Ferreira Gontijo-de-Amorim, Christina Maeda Takiya, Paola Romina Amable, Radovan Borojevic, Donatella Benati, Paolo Bernardi, Andrea Sbarbati

Registry-linked trialOpen access · bronzeAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aesthetic surgery journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03140319 (Autologous Transplantation of Cultured Fibroblast for Correction of Nasolabial Folds), which is not on this map. Cited by 55 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 5 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03140319 phase1 / phase2unknown statusnot on this mapstarted 2020, after this paper: background citation

Autologous Transplantation of Cultured Fibroblast for Correction of Nasolabial Folds

TypeinterventionalSponsorSCARM Institute, Tabriz, IranRan2020 to 2021Enrolled50ConditionsNasolabial Folds, Skin AgingArmsFibroblast, Placebo
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 5 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Platelet-Rich Plasma in Plastic Surgery: A Systematic Review.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2022
    Pooled it
  5. Pooled it
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. A New Era of Regenerative Medicine, With Longevity as the Cornerstone.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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  19. Article
  20. Stem cells in plastic surgery and aesthetic medicine.Postepy dermatologii i alergologii · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Gino RigottiDr Rigotti is Chief of Plastic and Regenerative Surgery, Regenerative Surgery Unit, San Francesco Clinic, Verona, Italy. Dr Charles-de-Sá is PhD student and Dr Takiya is a Professor, Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Dr Ferreira Gontijo-de-Amorim is a PhD course student at Verona University, Drs Benati and Berdardi are Researchers, and Dr Sbarbati is a Professor and Chief, Department of Neurological and Motor Science, Section of Anatomy and Histology, University of Verona, Italy. Dr Amable is a Researcher and Dr Borojevic is Chief, Excellion Biomedical Services, Petrópolis, Rio de Janeiro, Brazil.
Luiz Charles-de-SáDr Rigotti is Chief of Plastic and Regenerative Surgery, Regenerative Surgery Unit, San Francesco Clinic, Verona, Italy. Dr Charles-de-Sá is PhD student and Dr Takiya is a Professor, Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Dr Ferreira Gontijo-de-Amorim is a PhD course student at Verona University, Drs Benati and Berdardi are Researchers, and Dr Sbarbati is a Professor and Chief, Department of Neurological and Motor Science, Section of Anatomy and Histology, University of Verona, Italy. Dr Amable is a Researcher and Dr Borojevic is Chief, Excellion Biomedical Services, Petrópolis, Rio de Janeiro, Brazil.
Natale Ferreira Gontijo-de-AmorimDr Rigotti is Chief of Plastic and Regenerative Surgery, Regenerative Surgery Unit, San Francesco Clinic, Verona, Italy. Dr Charles-de-Sá is PhD student and Dr Takiya is a Professor, Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Dr Ferreira Gontijo-de-Amorim is a PhD course student at Verona University, Drs Benati and Berdardi are Researchers, and Dr Sbarbati is a Professor and Chief, Department of Neurological and Motor Science, Section of Anatomy and Histology, University of Verona, Italy. Dr Amable is a Researcher and Dr Borojevic is Chief, Excellion Biomedical Services, Petrópolis, Rio de Janeiro, Brazil.
Christina Maeda TakiyaDr Rigotti is Chief of Plastic and Regenerative Surgery, Regenerative Surgery Unit, San Francesco Clinic, Verona, Italy. Dr Charles-de-Sá is PhD student and Dr Takiya is a Professor, Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Dr Ferreira Gontijo-de-Amorim is a PhD course student at Verona University, Drs Benati and Berdardi are Researchers, and Dr Sbarbati is a Professor and Chief, Department of Neurological and Motor Science, Section of Anatomy and Histology, University of Verona, Italy. Dr Amable is a Researcher and Dr Borojevic is Chief, Excellion Biomedical Services, Petrópolis, Rio de Janeiro, Brazil.
Paola Romina AmableDr Rigotti is Chief of Plastic and Regenerative Surgery, Regenerative Surgery Unit, San Francesco Clinic, Verona, Italy. Dr Charles-de-Sá is PhD student and Dr Takiya is a Professor, Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Dr Ferreira Gontijo-de-Amorim is a PhD course student at Verona University, Drs Benati and Berdardi are Researchers, and Dr Sbarbati is a Professor and Chief, Department of Neurological and Motor Science, Section of Anatomy and Histology, University of Verona, Italy. Dr Amable is a Researcher and Dr Borojevic is Chief, Excellion Biomedical Services, Petrópolis, Rio de Janeiro, Brazil.
Radovan BorojevicDr Rigotti is Chief of Plastic and Regenerative Surgery, Regenerative Surgery Unit, San Francesco Clinic, Verona, Italy. Dr Charles-de-Sá is PhD student and Dr Takiya is a Professor, Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Dr Ferreira Gontijo-de-Amorim is a PhD course student at Verona University, Drs Benati and Berdardi are Researchers, and Dr Sbarbati is a Professor and Chief, Department of Neurological and Motor Science, Section of Anatomy and Histology, University of Verona, Italy. Dr Amable is a Researcher and Dr Borojevic is Chief, Excellion Biomedical Services, Petrópolis, Rio de Janeiro, Brazil.
Donatella BenatiDr Rigotti is Chief of Plastic and Regenerative Surgery, Regenerative Surgery Unit, San Francesco Clinic, Verona, Italy. Dr Charles-de-Sá is PhD student and Dr Takiya is a Professor, Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Dr Ferreira Gontijo-de-Amorim is a PhD course student at Verona University, Drs Benati and Berdardi are Researchers, and Dr Sbarbati is a Professor and Chief, Department of Neurological and Motor Science, Section of Anatomy and Histology, University of Verona, Italy. Dr Amable is a Researcher and Dr Borojevic is Chief, Excellion Biomedical Services, Petrópolis, Rio de Janeiro, Brazil.
Paolo BernardiDr Rigotti is Chief of Plastic and Regenerative Surgery, Regenerative Surgery Unit, San Francesco Clinic, Verona, Italy. Dr Charles-de-Sá is PhD student and Dr Takiya is a Professor, Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Dr Ferreira Gontijo-de-Amorim is a PhD course student at Verona University, Drs Benati and Berdardi are Researchers, and Dr Sbarbati is a Professor and Chief, Department of Neurological and Motor Science, Section of Anatomy and Histology, University of Verona, Italy. Dr Amable is a Researcher and Dr Borojevic is Chief, Excellion Biomedical Services, Petrópolis, Rio de Janeiro, Brazil.
Andrea SbarbatiDr Rigotti is Chief of Plastic and Regenerative Surgery, Regenerative Surgery Unit, San Francesco Clinic, Verona, Italy. Dr Charles-de-Sá is PhD student and Dr Takiya is a Professor, Postgraduate Program in Surgical Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Dr Ferreira Gontijo-de-Amorim is a PhD course student at Verona University, Drs Benati and Berdardi are Researchers, and Dr Sbarbati is a Professor and Chief, Department of Neurological and Motor Science, Section of Anatomy and Histology, University of Verona, Italy. Dr Amable is a Researcher and Dr Borojevic is Chief, Excellion Biomedical Services, Petrópolis, Rio de Janeiro, Brazil.
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn a previous study, the authors demonstrated that treatment with expanded adipose-derived stem cells or stromal vascular fraction (SVF)-enriched fat modify the pattern of the dermis in human beings, representing a skin rejuvenation effect. Considering that expanded stem cells require a cell factor, the authors wanted to assess similar results by replacing them with platelet-rich plasma (PRP), which is easier to obtain and for which an empirical regenerative effect has been already described.

objectivesTo determine if PRP injection could replace the cutaneous regenerative effect of adipose-derived stem cells.

methodsThis study was performed in 13 patients who were candidates for facelift. The patients underwent sampling of fat by liposuction from the abdomen and submitted to one of three protocols: injection of SVF-enriched fat or expanded adipose-derived stem cells or fat plus PRP in the preauricular areas. Fragments of skin were removed before and 3 months after treatment and analyzed by optical and electron microscopy.

resultsThe use of fat plus PRP led to the presence of more pronounced inflammatory infiltrates and a greater vascular reactivity, increasing in vascular permeability and a certain reactivity of the nervous component. The addition of PRP did not improve the regenerative effect.

conclusionThe use of PRP did not have significant advantages in skin rejuvenation over the use of expanded adipose-derived stem cells or SVF-enriched fat. The effect of increased vascular reactivity may be useful in pathological situations in which an intense angiogenesis is desirable, such as tissular ischemia.

Indexed as

Cosmetic TechniquesRejuvenationSkin AgingAdipose TissueAgedBrazilFemaleHumansLipectomyMaleMesenchymal Stem Cell TransplantationMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionMiddle AgedPlatelet-Rich PlasmaSkin

Identifiers

PMID26879294
PMCPMC5127465
OpenAlexW2287144139

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.