Evidence map›Paper›PMID 26879273›Full record

Observational studyCardiovascular diabetology2016

Early changes in cardiovascular structure and function in adolescents with type 1 diabetes.

Timothy J Bradley, Cameron Slorach, Farid H Mahmud, David B Dunger, John Deanfield, Livia Deda, Yesmino Elia, Ronnie L H Har, Wei Hui, Rahim Moineddin and 5 more

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05790785 (Understanding Vascular Complications in Children From Type 1 Diabetes Diagnosis), which is not on this map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05790785 recruitingnot on this mapstarted 2024, after this paper: background citation

Understanding Vascular Complications in Children From Type 1 Diabetes Diagnosis

TypeobservationalSponsorUniversity of British ColumbiaRan2024 to 2027Enrolled150ConditionsType 1 Diabetes, Cardiovascular Complications, Child, Adolescent
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  13. HInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Timothy J BradleyDepartment of Paediatrics, Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada. tjb1964@icloud.com.
Cameron SlorachDepartment of Paediatrics, Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada. cameron.slorach@sickkids.ca.
Farid H MahmudDepartment of Paediatrics, Division of Endocrinology, JDRF-Canadian Clinical Trial Network (JDRF-CCTN) Sick Kids Multicenter Clinical Trial Center, The Hospital for Sick Children, University of Toronto, Toronto, Canada. farid.mahmud@sickkids.ca.
David B DungerDepartment of Pediatrics, University of Cambridge, Cambridge, UK. dbd25@cam.ac.uk.
John DeanfieldUniversity College Hospital, London, UK. j.deanfield@ich.ucl.ac.uk.
Livia DedaDepartment of Paediatrics, Division of Endocrinology, JDRF-Canadian Clinical Trial Network (JDRF-CCTN) Sick Kids Multicenter Clinical Trial Center, The Hospital for Sick Children, University of Toronto, Toronto, Canada. livia.deda@sickkids.ca.
Yesmino EliaDepartment of Paediatrics, Division of Endocrinology, JDRF-Canadian Clinical Trial Network (JDRF-CCTN) Sick Kids Multicenter Clinical Trial Center, The Hospital for Sick Children, University of Toronto, Toronto, Canada. yesmino.elia@sickkids.ca.
Ronnie L H HarDepartment of Paediatrics, Division of Endocrinology, JDRF-Canadian Clinical Trial Network (JDRF-CCTN) Sick Kids Multicenter Clinical Trial Center, The Hospital for Sick Children, University of Toronto, Toronto, Canada. ronniehar@gmail.com.
Wei HuiDepartment of Paediatrics, Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada. wei.hui@sickkids.ca.
Rahim MoineddinDepartment of Family and Community Medicine, University of Toronto, Toronto, Canada. rahim.moineddin@sickkids.ca.
Heather N ReichDepartment of Medicine, Division of Nephrology, University Health Network, Toronto General Hospital, University of Toronto, 585 University Avenue, 8 N-845, Toronto, ON, M5G 2N2, Canada. heather.reich@uhn.ca.
James W ScholeyDepartment of Medicine, Division of Nephrology, University Health Network, Toronto General Hospital, University of Toronto, 585 University Avenue, 8 N-845, Toronto, ON, M5G 2N2, Canada. james.scholey@uhn.ca.
Luc MertensDepartment of Paediatrics, Division of Cardiology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada. luc.mertens@sickkids.ca.
Etienne SochettDepartment of Paediatrics, Division of Endocrinology, JDRF-Canadian Clinical Trial Network (JDRF-CCTN) Sick Kids Multicenter Clinical Trial Center, The Hospital for Sick Children, University of Toronto, Toronto, Canada. etienne.sochett@sickkids.ca.
David Z I CherneyDepartment of Medicine, Division of Nephrology, University Health Network, Toronto General Hospital, University of Toronto, 585 University Avenue, 8 N-845, Toronto, ON, M5G 2N2, Canada. david.cherney@uhn.ca.
University of Toronto · CAHospital for Sick Children · CAJuvenile Diabetes Research Foundation · CASickKids Foundation · CAToronto General Hospital · CAUniversity College London · GBUniversity Health Network · CAUniversity of Cambridge · GB

Funding

British Heart Foundation SP/07/002/23394
6 · The paper itself

Abstract

backgroundChildren with type 1 diabetes (T1D) are at higher risk of early adult-onset cardiovascular disease. We assessed cardiovascular structure and function in adolescents with T1D compared with healthy controls and the relationships between peripheral vascular function and myocardial parameters. METHODS AND

results199 T1D [14.4 ± 1.6 years, diabetes duration 6.2 (2.0-12.8) years] and 178 controls (14.4 ± 2.1 years) completed endothelial function by flow mediated vasodilatation (FMD), arterial stiffness using pulse wave velocity (PWV) along with M-mode, pulse wave and tissue Doppler, and myocardial deformation echocardiographic imaging. Systolic (113 ± 10 vs. 110 ± 9 mmHg; p = 0.0005) and diastolic (62 ± 7 vs. 58 ± 7 mmHg; p < 0.0001) blood pressures, carotid femoral PWV and endothelial dysfunction measurements were increased in T1D compared with controls. Systolic and diastolic left ventricular dimensions and function by M-mode and pulse wave Doppler assessment were not significantly different. Mitral valve lateral e' (17.6 ± 2.6 vs. 18.6 ± 2.6 cm/s; p < 0.001) and a' (5.4 ± 1.1 vs. 5.9 ± 1.1 cm/s; p < 0.001) myocardial velocities were decreased and E/e' (7.3 ± 1.2 vs. 6.7 ± 1.3; p = 0.0003) increased in T1D. Left ventricular mid circumferential strain (-20.4 ± 2.3 vs. -19.5 ± 1.7 %; p < 0.001) was higher, whereas global longitudinal strain was lower (-19.0 ± 1.9 vs. -19.8 ± 1.5 % p < 0.001) in T1D.

conclusionsAdolescents with T1D exhibit early changes in blood pressure, peripheral vascular function and left ventricular myocardial deformation indices with a shift from longitudinal to circumferential shortening. Longitudinal follow-up of these changes in ongoing prospective trials may allow detection of those most at risk for cardiovascular abnormalities including hypertension that could preferentially benefit from early therapeutic interventions.

Indexed as

AdolescentAge FactorsBlood PressureCase-Control StudiesChildDiabetes Mellitus, Type 1Disease ProgressionEarly DiagnosisEchocardiography, DopplerFemaleHumansLongitudinal StudiesMaleMitral ValveMyocardial ContractionPeripheral Arterial Disease

Identifiers

PMID26879273
PMCPMC4754808
OpenAlexW2280315107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.