ReviewHeart (British Cardiac Society)2016
Monitoring the biological activity of abdominal aortic aneurysms Beyond Ultrasound.
Review in Heart (British Cardiac Society), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- A Predictive Model for Major Adverse Aortic Events in Patients with Abdominal Aortic Aneurysm Using Clinical and Biomarker Data.International journal of molecular sciences · 2026Article
- Plasma Desmosine Is Elevated in Thoracoabdominal Aortic Aneurysms and Is Associated with Intramural Proteolytic Activity.International journal of molecular sciences · 2026Article
- Histomorphologic characteristics of abdominal aortic aneurysm samples are similar in abdominal-only vs thoracoabdominal involvement.JVS-vascular science · 2026Article
- Review
- Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis.Lipids in health and disease · 2025Article
- Factors Influencing Early Diagnosis of Ruptured Abdominal Aortic Aneurysms: The Role of Neutrophils.Journal of inflammation research · 2025Article
- CT analysis of aortic calcifications to predict abdominal aortic aneurysm rupture.European radiology · 2024Article
- Abdominal Aortic Aneurysm and PET/CT: From Molecular Mechanisms to Potential Molecular Imaging Targets.Reviews in cardiovascular medicine · 2023Review
- Editorial: Advances in aortic imaging.Frontiers in cardiovascular medicine · 2023Article
- Assessment of different quantification metrics of [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Abdominal Aortic Aneurysm Formation with a Focus on Vascular Smooth Muscle Cells.Life (Basel, Switzerland) · 2022Review
- Iterative reconstruction incorporating background correction improves quantification of [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Circulating Biomarkers for the Prediction of Abdominal Aortic Aneurysm Growth.Journal of clinical medicine · 2021Review
- Beyond Vessel Diameters: Non-invasive Monitoring of Flow Patterns and Immune Cell Recruitment in Murine Abdominal Aortic Disorders by Multiparametric MRI.Frontiers in cardiovascular medicine · 2021Article
- The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases.International journal of molecular sciences · 2020Review
- Predicting abdominal aortic aneurysm growth using patient-oriented growth models with two-step Bayesian inference.Computers in biology and medicine · 2020Article
- Emerging techniques in atherosclerosis imaging.The British journal of radiology · 2019Review
- Plasma Desmosine and Abdominal Aortic Aneurysm Disease.Journal of the American Heart Association · 2019Observational
- Aortic aneurysm in patients undergoing transcatheter aortic valve implantation: A prognostic determinant? or just an innocent bystander?Indian heart journal · 2018Article
- Predictions and insights for the abdominal aortic aneurysm.Journal of thoracic disease · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Abdominal aortic aneurysms (AAAs) are an important cause of morbidity and, when ruptured, are associated with >80% mortality. Current management decisions are based on assessment of aneurysm diameter by abdominal ultrasound. However, AAA growth is non-linear and rupture can occur at small diameters or may never occur in those with large AAAs. There is a need to develop better imaging biomarkers that can identify the potential risk of rupture independent of the aneurysm diameter. Key pathobiological processes of AAA progression and rupture include neovascularisation, necrotic inflammation, microcalcification and proteolytic degradation of the extracellular matrix. These processes represent key targets for emerging imaging techniques and may confer an increased risk of expansion or rupture over and above the known patient-related risk factors. Magnetic resonance imaging, using ultrasmall superparamagnetic particles of iron oxide, can identify and track hotspots of macrophage activity. Positron emission tomography, using a variety of targeted tracers, can detect areas of inflammation, angiogenesis, hypoxia and microcalcification. By going beyond the simple monitoring of diameter expansion using ultrasound, these cellular and molecular imaging techniques may have the potential to allow improved prediction of expansion or rupture and to better guide elective surgical intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.