Observational studyOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016
Lower leg muscle density is independently associated with fall status in community-dwelling older adults.
Observational study in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exercise for improving age-related hyperkyphosis: a systematic review and meta-analysis with GRADE assessment.Archives of osteoporosis · 2021Pooled it
- Bushen Yijing Fang Reduces Fall Risk in Late Postmenopausal Women with Osteopenia: A Randomized Double-blind and Placebo-controlled Trial.Scientific reports · 2019Trial
- Underexplored terrain: effects of high priority environmental toxicants on skeletal muscle.Journal of toxicology and environmental health. Part B, Critical reviews · 2026Review
- Associations Between Deep Learning-Derived Fat, Muscle, and Bone Measures From Abdominal Computed Tomography Scans and Fall Risk in Persons Aged 20 Years or Older.Mayo Clinic proceedings. Digital health · 2025Article
- Exercise and dietary recommendations to preserve musculoskeletal health during weight loss in adults with obesity: A practical guide.Reviews in endocrine & metabolic disorders · 2025Review
- Creatine monohydrate supplementation for older adults and clinical populations.Journal of the International Society of Sports Nutrition · 2025Review
- Muscle Biomarkers as Molecular Signatures for Early Detection and Monitoring of Muscle Health in Aging.Nutrients · 2025Review
- The role of proximal femoral bone, muscle and subcutaneous adipose tissue in the discriminating of hip fracture types in elderly women.BMC musculoskeletal disorders · 2025Article
- Review
- The Mediating Role of Cognitive Function in the Relationship Between Physical Performance and Depressive Symptoms Among Older Adults in China: A Prospective Longitudinal Study.Nursing research and practice · 2025Article
- Comparison study of bioelectrical impedance analyzers for measuring lower limb muscle mass in middle-aged and elderly adults.Frontiers in nutrition · 2025Article
- Assessment of myosteatosis and functionality in pretreatment gynecological cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Impact of a Whole-Food, High-Soluble Fiber Diet on the Gut-Muscle Axis in Aged Mice.Nutrients · 2024Article
- Relationship between Acceleration in a Sit-To-Stand Movement and Physical Function in Older Adults.Geriatrics (Basel, Switzerland) · 2023Article
- A comprehensive review on the risks assessment and treatment options for Sarcopenia in people with diabetes.Journal of diabetes and metabolic disorders · 2023Review
- Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults: Established and Emerging Treatments and Therapies.Diabetes & metabolism journal · 2023Review
- Fatty infiltration of hip muscles and trochanteric soft tissue thickness are associated with hip fractures in the elderly.International orthopaedics · 2022Article
- Computed tomography-based paravertebral muscle density predicts subsequent vertebral fracture risks independently of bone mineral density in postmenopausal women following percutaneous vertebral augmentation.Aging clinical and experimental research · 2022Article
- Prevalence of sarcopenia in patients with rheumatoid arthritis using the revised EWGSOP2 and the FNIH definition.RMD open · 2022Observational
- Differences in Muscle Quantity and Quality by HIV Serostatus and Sex.The Journal of frailty & aging · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
unlabelledMuscle density is a risk factor for fractures in older adults; however, its association with falls is not well described. After adjusting for biologically relevant confounding factors, a unit decrease in muscle density was associated with a 17 % increase in odds of reporting a fall, independent of functional mobility.
introductionFalls are the leading cause of injury, disability, and fractures in older adults. Low muscle density (i.e., caused by muscle adiposity) and functional mobility have been identified as risk factors for incident disability and fractures in older adults; however, it is not known if these are also independently associated with falls. The purpose of this study was to explore the associations of muscle density and functional mobility with fall status.
methodsCross-sectional observational study of 183 men and women aged 60-98 years. Descriptive data, including a 12-month fall recall, Timed Up and Go (TUG) test performance, lower leg muscle area, and density. Odds ratio (OR) of being a faller were calculated, adjusted for age, sex, body mass index, general health status, diabetes, and comorbidities.
resultsEvery mg/cm(3) increase in muscle density (mean 70.2, SD 2.6 mg/cm(3)) independently reduced the odds of being a faller by 19 % (OR 0.81 [95 % CI 0.67 to 0.97]), and every 1 s longer TUG test time (mean 9.8, SD 2.6 s) independently increased the odds by 17 % (OR 1.17 [95 % CI 1.01 to 1.37]). When both muscle density and TUG test time were included in the same model, only age (OR 0.93 [95 % CI 0.87 to 0.99]) and muscle density (OR 0.83 [95 % CI 0.69 to 0.99]) were independently associated with fall status.
conclusionsMuscle density was associated with fall status, independent of functional mobility. Muscle density may compliment functional mobility tests as a biometric outcome for assessing fall risk in well-functioning older adults.
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Registered trials
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