Evidence map›Paper›PMID 26879184›Full record

ArticleAIDS research and human retroviruses

The Impact of Sex Work Interruption on Blood-Derived T Cells in Sex Workers from Nairobi, Kenya.

Kenneth Omollo, Geneviève Boily-Larouche, Julie Lajoie, Makobu Kimani, Julianna Cheruiyot, Joshua Kimani, Julius Oyugi, Keith Raymond Fowke

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. HIV-Exposed Seronegative Female Sex Workers Show Different Cellular Immune Profiles Across the Menstrual Cycle.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Article
  2. Article
  3. Article
  4. Differential Elevation of Inflammation and CD4Frontiers in immunology · 2020
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kenneth Omollo1 Department of Medical Microbiology, University of Nairobi , Nairobi, Kenya .
Geneviève Boily-Larouche2 Department of Medical Microbiology, University of Manitoba , Winnipeg, Manitoba, Canada .
Julie Lajoie1 Department of Medical Microbiology, University of Nairobi , Nairobi, Kenya .
Makobu Kimani3 Kenyan AIDS Control Program, University of Nairobi , Nairobi, Kenya .
Julianna Cheruiyot3 Kenyan AIDS Control Program, University of Nairobi , Nairobi, Kenya .
Joshua Kimani1 Department of Medical Microbiology, University of Nairobi , Nairobi, Kenya .
Julius Oyugi1 Department of Medical Microbiology, University of Nairobi , Nairobi, Kenya .
Keith Raymond Fowke1 Department of Medical Microbiology, University of Nairobi , Nairobi, Kenya .
Kenya AIDS Vaccine Initiative · KEUniversity of Manitoba · CAUniversity of Nairobi · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnprotected sexual intercourse exposes the female genital tract (FGT) to semen-derived antigens, which leads to a proinflammatory response. Studies have shown that this postcoital inflammatory response can lead to recruitment of activated T cells to the FGT, thereby increasing risk of HIV infection.

objectiveThe purpose of this study was to evaluate the impact of sex work on activation and memory phenotypes of peripheral T cells among female sex workers (FSW) from Nairobi, Kenya. SUBJECTS: Thirty FSW were recruited from the Pumwani Sex Workers Cohort, 10 in each of the following groups: HIV-exposed seronegative (at least 7 years in active sex work), HIV positive, and New Negative (HIV negative, less than 3 years in active sex work). Blood was obtained at three different phases (active sex work, abstinence from sex work-sex break, and following resumption of sex work). Peripheral blood mononuclear cells were isolated and stained for phenotypic markers (CD3, CD4, CD8, and CD161), memory phenotype markers (CD45RA and CCR7), activation markers (CD69, HLA-DR, and CD95), and the HIV coreceptor (CCR5). T-cell populations were compared between groups.

resultsIn HIV-positive women, CD8+CCR5+ T cells declined at the sex break period, while CD4+CD161+ T cells increased when returning to sex work. All groups showed no significant changes in systemic T-cell activation markers following the interruption of sex work, however, significant reductions in naive CD8+ T cells were noted. For each of the study points, HIV positives had higher effector memory and CD8+CD95+ T cells and lower naive CD8+ T cells than the HIV-uninfected groups.

conclusionsInterruption of sex work had subtle effects on systemic T-cell memory phenotypes.

Indexed as

Occupational ExposureSex WorkersAdultAntigens, CDCohort StudiesFemaleHumansKenyaMiddle AgedT-Lymphocyte SubsetsAntigens, CDHIVHIV-exposed seronegativeimmune activationperipheral blood mononuclear cellssex workT cell memory

Identifiers

PMID26879184
PMCPMC5067831
OpenAlexW2297111105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.