ArticleHarm reduction journal2016
Opioid tolerance in methadone maintenance treatment: comparison of methadone and levomethadone in long-term treatment.
Article in Harm reduction journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06946290 (Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intertransverse Process Block to Improve Quality of Recovery and Pain Management in Adult Cardiac Surgical Patients: a Prospective Double-Blinded Randomized Controlled Trial
Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Intravenous methadone for pain management in cardiac surgery: a randomised controlled trial with plasma concentration analysis.Anaesthesia · 2026Trial
- Levomethadone Selectively Reduces Emotional Impulsivity in ASRS-Positive ADHD-OUD Patients, Independent of Dose Escalation.Journal of clinical medicine · 2025Article
- Article
- [Challenges in the treatment of opioid dependence].Der Nervenarzt · 2024Review
- Article
- Call for the Standardization of Opioid Related Terminologies.Translational perioperative and pain medicine · 2024Article
- Lapse and Relapse Rates in Narcotics Anonymous versus Methadone Maintenance Treatment: A 12-Month Prospective Study.Iranian journal of psychiatry · 2022Article
- New Approaches in Drug Dependence: Opioids.Current addiction reports · 2021Review
- To Stop or Not, That Is the Question: Acute Pain Management for the Patient on Chronic Buprenorphine.Anesthesiology · 2017Review
- An overview of available drugs for management of opioid abuse during pregnancy.Maternal health, neonatology and perinatology · 2017Review
- Reasons for Increasing Daily Methadone Maintenance Dosage among Deceptive Patients: A Qualitative Study.Journal of medicine and lifeArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to investigate the development of opioid tolerance in patients receiving long-term methadone maintenance treatment (MMT).
methodsA region-wide cross-sectional study was performed focusing on dosage and duration of treatment. Differences between racemic methadone and levomethadone were examined. All 20 psychiatric hospitals and all 110 outpatient clinics in Berlin licensed to offer MMT were approached in order to reach patients under MMT fulfilling the DSM IV criteria of opiate dependence. In the study, 720 patients treated with racemic methadone or levomethadone gave information on the dosage of treatment. Out of these, 679 patients indicated the duration of MMT.
resultsTreatment with racemic methadone was reported for 370 patients (54.5%), with levomethadone for 309 patients (45.5%). Mean duration of MMT was 7.5 years. We found a significant correlation between dosage and duration of treatment, both in a conjoint analysis for the two substances racemic methadone and levomethadone and for each substance separately. These effects remained significant when only patients receiving MMT for 1 year or longer were considered, indicating proceeding tolerance development in long-term treatment. When correlations were compared between racemic methadone and levomethadone, no significant difference was found.
conclusionsOur data show a tolerance development under long-term treatment with both racemic methadone and levomethadone. Tolerance development did not differ significantly between the two substances.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.