ArticleScientific reports2016
Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Adaptations of the balloon analog risk task for neuroimaging settings: a systematic review.Frontiers in neuroscience · 2023Pooled it
- Risk-taking in the human brain: An activation likelihood estimation meta-analysis of the balloon analog risk task (BART).Human brain mapping · 2022Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Common and distinct brain activity associated with risky and ambiguous decision-making.Drug and alcohol dependence · 2020Pooled it
- Nicotinic modulation of salience network connectivity and centrality in schizophrenia.Journal of psychiatric research · 2017Trial
- Neurobehavioral Heterogeneity in Problem Gambling Severity and Nicotine Use Risk: Divergent Profiles of Cognitive and Emotional Control.Journal of gambling studies · 2026Article
- Modulation of High-Frequency rTMS on Reward Circuitry in Individuals with Nicotine Dependence: A Preliminary fMRI Study.Neural plasticity · 2024Article
- Effect of real-world fear on risky decision-making in medical school-based students: A quasi-experimental study.Frontiers in behavioral neuroscience · 2023Article
- Effective brain connectivity at rest is associated with choice-induced preference formation.Human brain mapping · 2020Article
- Robust functional mapping of layer-selective responses in human lateral geniculate nucleus with high-resolution 7T fMRI.Proceedings. Biological sciences · 2020Article
- Acute and Chronic Effects of Betel Quid Chewing on Brain Functional Connectivity.Frontiers in psychiatry · 2020Article
- The Insula: A Brain Stimulation Target for the Treatment of Addiction.Frontiers in pharmacology · 2019Review
- Risk seeking for losses modulates the functional connectivity of the default mode and left frontoparietal networks in young males.Cognitive, affective & behavioral neuroscience · 2018Article
- The thalamus in drug addiction: from rodents to humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Moderating Effects of Harm Avoidance on Resting-State Functional Connectivity of the Anterior Insula.Frontiers in human neuroscience · 2018Article
- Why are Antidepressant Drugs Effective Smoking Cessation Aids?Current neuropharmacology · 2018Review
- Resting-State Functional Connectivity of the Basal Nucleus of Meynert in Cigarette Smokers: Dependence Level and Gender Differences.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Hyper-resting brain entropy within chronic smokers and its moderation by Sex.Scientific reports · 2016Article
- Romantic Love vs. Drug Addiction May Inspire a New Treatment for Addiction.Frontiers in psychology · 2016Review
- Cognitive Dysfunction, Affective States, and Vulnerability to Nicotine Addiction: A Multifactorial Perspective.Frontiers in psychiatry · 2016Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotine addiction is associated with risky behaviors and abnormalities in local brain areas related to risky decision-making such as the dorsal anterior cingulate cortex (dACC), anterior insula (AI), and thalamus. Although these brain abnormalities are anatomically separated, they may in fact belong to one neural network. However, it is unclear whether circuit-level abnormalities lead to risky decision-making in smokers. In the current study, we used task-based functional magnetic resonance imaging (fMRI) and examined resting-state functional connectivity (RSFC) to study how connectivity between the dACC, insula, and thalamus influence risky decision-making in nicotine addicts. We found that an increase in risky decision-making was associated with stronger nicotine dependence and stronger RSFC of the dACC-rAI (right AI), the dACC-thalamus, the dACC-lAI (left AI), and the rAI-lAI, but that risky decision-making was not associated with risk level-related activation. Furthermore, the severity of nicotine dependence positively correlated with RSFC of the dACC-thalamus but was not associated with risk level-related activation. Importantly, the dACC-thalamus coupling fully mediated the effect of nicotine-dependent severity on risky decision-making. These results suggest that circuit-level connectivity may be a critical neural link between risky decision-making and severity of nicotine dependence in smokers.
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