SynthesisBMC musculoskeletal disorders2016
The efficacy of topical tranexamic acid in total hip arthroplasty: a meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Blood-saving Effect of Combined Intravenous Tranexamic Acid With Topical Floseal® Application, a Comparison With Intravenous Tranexamic Acid Only in Total Hip Arthroplasty
Efficacy of Tranexamic Acid in Femoral Shaft Fractures Osteosynthesis; A Double Blind Randomized Controlled Trial
Who cites it
35 citing papers in PubMed, 12 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Efficacy and Safety of Combined Carbazochrome Sodium Sulfonate and Tranexamic Acid for Blood Loss Control in Patients Undergoing Total Hip Arthroplasty: A Systematic Review and Meta-Analysis.Iranian journal of medical sciences · 2026Pooled it
- Pooled it
- Tranexamic acid usage in hip fracture surgery: a meta-analysis and meta-regression analysis of current practice.Archives of orthopaedic and trauma surgery · 2022Pooled it
- Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials.BioMed research international · 2021Pooled it
- Does Aprotinin Reduce the Blood Loss after Total Hip Arthroplasty? A Meta-analysis of Randomized Controlled Trials.Orthopaedic surgery · 2019Pooled it
- Pooled it
- Tranexamic acid in total shoulder arthroplasty and reverse shoulder arthroplasty: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2018Pooled it
- Combined application versus topical and intravenous application of tranexamic acid following primary total hip arthroplasty: a meta-analysis.BMC musculoskeletal disorders · 2017Pooled it
- Efficacy and safety of tranexamic acid in reducing blood loss in scoliosis surgery: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Pooled it
- Pooled it
- A systematic review of tranexamic acid in hip fracture surgery.British journal of clinical pharmacology · 2016Pooled it
- Intravenous versus topical tranexamic acid in primary total hip replacement: A meta-analysis.Medicine · 2016Pooled it
- Efficacy and safety of topical application of tranexamic acid in patients undergoing reconstructive plastic surgery after excision of facial skin cancers: a randomised clinical trial.Revista do Colegio Brasileiro de Cirurgioes · 2024Trial
- A prospective randomized study, use of closed suction drainage after revision hip arthroplasty may lead to excessive blood loss.Scientific reports · 2022Trial
- Comparative study of suction drainage placement in cementless hip replacement among patients undergoing extended thromboprophylaxis: a prospective randomized study.BMC musculoskeletal disorders · 2021Trial
- Clinical and instrumental evaluation of two different regimens of tranexamic acid in total hip arthroplasty: a single-centre, prospective, randomized study with 80 patients.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018Trial
- Risk-stratified perioperative tranexamic acid utilization for total hip and knee arthroplasty: Analysis of trends of the past decade.Bulletin of the Hospital for Joint Disease (2013) · 2026Article
- Effect of Routes of Administration of Tranexamic Acid in Peri-Operative Blood Loss in Total Hip Arthroplasty: A Prospective Comparative Study.Journal of orthopaedic case reports · 2026Article
- Topical tranexamic acid in hip and knee surgery: a meta-analysis of randomized-controlled trials.EFORT open reviews · 2025Article
- Comparing residual thrombosis and venous thromboembolism outcomes between patients treated with or without anticoagulant therapy for acute distal lower-limb deep vein thrombosis after total hip arthroplasty.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTopical tranexamic acid (TXA) has been shown to be effective in reducing blood loss and the need for transfusion after total knee arthroplasty. However, the effectiveness of topical TXA use in total hip arthroplasty (THA) still remains unclear. The purpose of this meta-analysis is to examine the safety and efficacy of topical use of TXA following THA. HYPOTHESIS: Topical TXA reduces blood loss and transfusion rates without increasing risk of deep vein thrombosis in patients with THA.
methodsAn electronic literature search of PubMed, Embase, the Cochrane Library, Web of Science and Chinese Biomedical Database was performed, to identify studies published before February 2015. All randomized controlled trials and cohort studies evaluating the efficacy of topical TXA during THA were included. Two independent authors identified the eligible studies, assessed their methodological quality, and extracted data. The data were using fixed-effects or random-effects models with (standard) mean differences and risk ratios for continuous and dichotomous variables, respectively. Data were analysed using RevMan 5.3 software.
resultsFourteen studies encompassing 2594 patients met the inclusion criteria for our meta-analysis. Our meta-analysis indicated that when compared with the placebo group, topical use of TXA significantly reduced total blood loss (MD = -297.65 ml, 95 % CI -371.68 ml, 116.08 ml; P < 0.01), drainage loss (MD = -164.68 ml, 95 % CI -236.63 ml, -92.73 ml; P < 0.01), transfusion rate (RR = 0.26, 95 % CI 0.17, 0.40; P < 0.01) and with less of a drop in haemoglobin level (SMD = -0.66, 95 % CI -0.91, -0.41; P < 0.01) after primary THA. No significant difference in length of hospital stay (MD = -0.40, 95 % CI -0.91, 0.11; P = 0.14), deep vein thrombosis (RR = 1.19, 95 % CI 0.40, 3.57; P = 0.16) and pulmonary embolism (RR = 1.11, 95 % CI 0.11, 10.81; P = 0.21) among the study groups.
conclusionsTopical TXA could significantly reduce total blood loss, drainage loss, transfusion rates and decrease haemoglobin level following THA, without increasing risk of venous thromboembolisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.