ArticleImmunology2016
Murine Sertoli cells promote the development of tolerogenic dendritic cells: a pivotal role of galectin-1.
Article in Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation.Seminars in immunopathology · 2026Review
- Advances in immunological research on male infertility.Frontiers in reproductive health · 2026Review
- Immune Microenvironment Dysregulation: A Contributing Factor to Obesity-Associated Male Infertility.Biomedicines · 2025Review
- Galectin-1 and galectin-3 in male reproduction - impact in health and disease.Seminars in immunopathology · 2025Review
- Isolation of Pig or Rodent Sertoli Cells for Use in Transplantation.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Immune Regulation in the Testis and Epididymis.Advances in experimental medicine and biology · 2025Review
- Testicular immunity.Molecular aspects of medicine · 2024Review
- Therapeutic potential of Sertoli cells in vivo: alleviation of acute inflammation and improvement of sperm quality.Stem cell research & therapy · 2024Article
- 9-cis-retinoic acid signaling in Sertoli cells regulates their immunomodulatory function to control lymphocyte physiology and Treg differentiation.Reproductive biology and endocrinology : RB&E · 2024Article
- Galectin-1: A Traditionally Immunosuppressive Protein Displays Context-Dependent Capacities.International journal of molecular sciences · 2023Review
- The Role of Mononuclear Phagocytes in the Testes and Epididymis.International journal of molecular sciences · 2022Review
- Sertoli Cell Immune Regulation: A Double-Edged Sword.Frontiers in immunology · 2022Review
- The Good, the Bad and the Ugly of Testicular Immune Regulation: A Delicate Balance Between Immune Function and Immune Privilege.Advances in experimental medicine and biology · 2021Review
- Impacts of Immunometabolism on Male Reproduction.Frontiers in immunology · 2021Review
- Integrating miRNA and mRNA Profiling to Assess the Potential miRNA-mRNA Modules Linked With Testicular Immune Homeostasis in Sheep.Frontiers in veterinary science · 2021Article
- Hypertension and reproductive dysfunction: a possible role of inflammation and inflammation-associated lymphangiogenesis in gonads.Clinical science (London, England : 1979) · 2020Review
- Immune Cell Subtypes and Their Function in the Testis.Frontiers in immunology · 2020Review
- Infectious, inflammatory and 'autoimmune' male factor infertility: how do rodent models inform clinical practice?Human reproduction update · 2018Review
- Galectin-1 enhances TNFα-induced inflammatory responses in Sertoli cells through activation of MAPK signalling.Scientific reports · 2018Article
- Cytokines in Male Fertility and Reproductive Pathologies: Immunoregulation and Beyond.Frontiers in endocrinology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sertoli cells (SCs) possess inherent immunosuppressive properties and are major contributors to the immunoprivileged status of mammalian testis. SCs have been reported to inhibit the activation of B cells, T cells and natural killer cells but not dendritic cells (DCs). Herein, we present evidence that co-culture with SCs results in a persistent state of DC immaturity characterized by down-regulation of the surface molecules I-A/E, CD80, CD83, CD86, CCR7 and CD11c, as well as reduced production of pro-inflammatory cytokines. SC-conditioned DCs (SC-DCs) displayed low immunogenicity and enhanced immunoregulatory functions, including the inhibition of T-cell proliferation and the promotion of Foxp3(+) regulatory T-cell development. Mechanistically, the activation of p38, extracellular signal-regulated kinase 1/2, and signal transducer and activator of transcription 3 was suppressed in SC-DCs. More importantly, we demonstrate that galectin-1 secreted by SCs plays a pivotal role in the differentiation of functionally tolerogenic SC-DCs. These findings further support the role of SCs in maintaining the immunoprivileged environment of the testis and provide a novel approach to derive tolerogenic DCs, which may lead to alternative therapeutic strategies for the treatment of immunopathogenic diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.