ArticleNature biotechnology2016
A 3D bioprinting system to produce human-scale tissue constructs with structural integrity.
Article in Nature biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04748016 (Sterilised 3D-PRINTed Bone Models in Addition to Conventional CT Imaging for Operative Visualisation in Complex Intra-articular Fracture Repair - A Multi-centre, Double-blind Randomised Controlled Trial), which is not on this map. Cited by 854 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sterilised 3D-PRINTed Bone Models in Addition to Conventional CT Imaging for Operative Visualisation in Complex Intra-articular Fracture Repair - A Multi-centre, Double-blind Randomised Controlled Trial
Who cites it
854 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction.Bioactive materials · 2027Review
- The Allstruder: an open syringe extruder for every 3D printer.HardwareX · 2026Article
- Stem cell derived neural organoid approaches for neurological diseases.Neural regeneration research · 2026Article
- RETRACTED: Surgery in space: The ultimate frontier.Experimental physiology · 2026Article
- Modular living assembly of bone organoids with in situ guided vascularization.Bioactive materials · 2026Article
- Biotube/Biosheet as a collagen-based scaffold for vaginal reconstruction: evaluation in a rat model.Pediatric surgery international · 2026Article
- Three-Dimensional Bioprinting in Reconstructive Plastic Surgery: A Comprehensive Review.Cells · 2026Review
- Heat-Suppressing Projection Two-Photon Lithography Enables High-Throughput Sub-Micrometer Manufacturing of Biopolymer Hydrogels for Tissue Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Water-state control unlocks durable and elastic silk fibroin hydrogels.Nature communications · 2026Article
- Applications of Nanofabrication Technologies in the Preparation of Biomimetic Structures.Biomimetics (Basel, Switzerland) · 2026Review
- Accessible Biofabrication of Anatomically Inspired Hollow and Branched Hydrogel Constructs by Soft Templating (Sof-T).Bioengineering (Basel, Switzerland) · 2026Article
- Tissue Engineering for Massive Bone Defects: The Volumetric Scaling Problem and Strategies to Solve It.Bioengineering (Basel, Switzerland) · 2026Review
- Review
- The Next Phase of 3D Bioprinting: AI-Native Systems-A Narrative Review.Journal of functional biomaterials · 2026Review
- Photothermal Ablation Blotting for Capillary-Scale Microvasculature Engineering.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Cryopreservative Bioink Enables Direct Bioprinting of Adherent Cells.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Computational design of artificial supply networks for engineered human tissue.Scientific reports · 2026Article
- Role of polymeric nanocomposite for tissue engineering applications.RSC advances · 2026Review
- Engineering anisotropic tissues: from structured scaffolds to magnetic actuation.Materials today. Bio · 2026Review
794 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A challenge for tissue engineering is producing three-dimensional (3D), vascularized cellular constructs of clinically relevant size, shape and structural integrity. We present an integrated tissue-organ printer (ITOP) that can fabricate stable, human-scale tissue constructs of any shape. Mechanical stability is achieved by printing cell-laden hydrogels together with biodegradable polymers in integrated patterns and anchored on sacrificial hydrogels. The correct shape of the tissue construct is achieved by representing clinical imaging data as a computer model of the anatomical defect and translating the model into a program that controls the motions of the printer nozzles, which dispense cells to discrete locations. The incorporation of microchannels into the tissue constructs facilitates diffusion of nutrients to printed cells, thereby overcoming the diffusion limit of 100-200 μm for cell survival in engineered tissues. We demonstrate capabilities of the ITOP by fabricating mandible and calvarial bone, cartilage and skeletal muscle. Future development of the ITOP is being directed to the production of tissues for human applications and to the building of more complex tissues and solid organs.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.