Evidence map›Paper›PMID 26878311›Full record

ArticleCognitive neuropsychiatry2016

The doxastic shear pin: delusions as errors of learning and memory.

S K Fineberg, P R Corlett

Abstract read
In one paragraph

Article in Cognitive neuropsychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Resolving the Delusion Paradox.Schizophrenia bulletin · 2023
    Review
  5. Paranoia, self-deception and overconfidence.PLoS computational biology · 2021
    Article
  6. Article
  7. Are clinical delusions adaptive?Wiley interdisciplinary reviews. Cognitive science · 2019
    Review
  8. The Predictive Coding Account of Psychosis.Biological psychiatry · 2018
    Review
  9. Article
  10. Review
  11. A Predictive Coding Account of Psychotic Symptoms in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2017
    Article
  12. Review
  13. Prediction error, ketamine and psychosis: An updated model.Journal of psychopharmacology (Oxford, England) · 2016
    Review
  14. Depressive delusions.Filosofia unisinos = Unisinos journal of philosophy · 2016
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

S K Fineberga Department of Psychiatry, Ribicoff Research Facility , Yale University , New Haven , CT , USA.
P R Corletta Department of Psychiatry, Ribicoff Research Facility , Yale University , New Haven , CT , USA.

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Clinical Neuroscience Research Training Program in PsychiatryT32MH019961 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 1996 to 2026
$5.9M
NCATS NIH HHS UL1 TR000142NIMH NIH HHS 5T32MH019961NIMH NIH HHS T32 MH019961
6 · The paper itself

Abstract

We reconsider delusions in terms of a "doxastic shear pin", a mechanism that errs so as to prevent the destruction of the machine (brain) and permit continued function (in an attenuated capacity). Delusions may disable flexible (but energetically expensive) inference. With each recall, delusions may be reinforced further and rendered resistant to contradiction. We aim to respond to deficit accounts of delusions - that delusions are only a problem without any benefit - by considering delusion formation and maintenance in terms of predictive coding. We posit that brains conform to a simple computational principle: to minimize prediction error (the mismatch between prior top-down expectation and current bottom-up input) across hierarchies of brain regions and psychological representation. Recent data suggest that delusions may form in the absence of constraining top-down expectations. Then, once formed, they become new priors that motivate other beliefs, perceptions, and actions by providing strong (sometimes overriding) top-down expectation. We argue that delusions form when the shear-pin breaks, permitting continued engagement with an overwhelming world, and ongoing function in the face of paralyzing difficulty. This crucial role should not be ignored when we treat delusions: we need to consider how a person will function in the world without them..

Indexed as

LearningMemoryAssociation LearningBrainCapgras SyndromeDelusionsHumansKnowledgeMental RecallMotivationPsychological TheoryBeliefdelusionepistemic benefitprediction errorschizophrenia

Identifiers

PMID26878311
PMCPMC5790119

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.