ArticleNature2016
Evidence from cyclostomes for complex regionalization of the ancestral vertebrate brain.
Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Reassessing forebrain organization: recent evidence challenges the prosomere model.Current opinion in genetics & development · 2026Review
- Article
- A 3D amphioxus brain atlas illuminates the blueprint of the ancestral chordate brain and highlights unique vertebrate innovations.Science advances · 2026Article
- Fgf evolution in vertebrates: insights from cyclostomes.BMC genomics · 2026Article
- Differential tissue deformability underlies fluid pressure-driven shape divergence of the avian embryonic brain and spinal cord.Developmental cell · 2025Article
- Comparative study on a unique architecture of the brook lamprey liver and that of the hagfish and banded houndshark liver.Cell and tissue research · 2024Article
- Fibroblast growth factor signalling regulates the development of tooth root.Journal of anatomy · 2024Article
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- Musculoskeletal morphogenesis supports the convergent evolution of bat laryngeal echolocation.Proceedings. Biological sciences · 2024Article
- Turtle skull development unveils a molecular basis for amniote cranial diversity.Science advances · 2023Article
- A lamprey neural cell type atlas illuminates the origins of the vertebrate brain.Nature ecology & evolution · 2023Article
- Phylogenetic tracing of midbrain-specific regulatory sequences suggests single origin of eubilaterian brains.Science advances · 2023Article
- ThreeFrontiers in cell and developmental biology · 2023Article
- Thyroid and endostyle development in cyclostomes provides new insights into the evolutionary history of vertebrates.BMC biology · 2022Article
- Review
- Humans, fish, spiders and bees inherited working memory and attention from their last common ancestor.Frontiers in psychology · 2022Article
- The Dopaminergic Control of Movement-Evolutionary Considerations.International journal of molecular sciences · 2021Review
- The dorsoanterior brain of adult amphioxus shares similarities in expression profile and neuronal composition with the vertebrate telencephalon.BMC biology · 2021Article
- Review
- The emergence of the brain non-CpG methylation system in vertebrates.Nature ecology & evolution · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vertebrate brain is highly complex, but its evolutionary origin remains elusive. Because of the absence of certain developmental domains generally marked by the expression of regulatory genes, the embryonic brain of the lamprey, a jawless vertebrate, had been regarded as representing a less complex, ancestral state of the vertebrate brain. Specifically, the absence of a Hedgehog- and Nkx2.1-positive domain in the lamprey subpallium was thought to be similar to mouse mutants in which the suppression of Nkx2-1 leads to a loss of the medial ganglionic eminence. Here we show that the brain of the inshore hagfish (Eptatretus burgeri), another cyclostome group, develops domains equivalent to the medial ganglionic eminence and rhombic lip, resembling the gnathostome brain. Moreover, further investigation of lamprey larvae revealed that these domains are also present, ruling out the possibility of convergent evolution between hagfish and gnathostomes. Thus, brain regionalization as seen in crown gnathostomes is not an evolutionary innovation of this group, but dates back to the latest vertebrate ancestor before the divergence of cyclostomes and gnathostomes more than 500 million years ago.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.