Evidence map›Paper›PMID 26878074›Full record

ArticleInternational journal of immunotherapy and cancer research

Endothelial Progenitor Cells in Breast Cancer.

Monica C Botelho, Helena Alves

Abstract read
In one paragraph

Article in International journal of immunotherapy and cancer research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Significance of Cancer Stem Cells in Anti-Cancer Therapies.International journal of immunotherapy and cancer research · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Monica C BotelhoINSA, National Institute of Health Dr. Ricardo Jorge, Porto, Portugal; IPATIMUP/I3S, Institute of Pathology and Molecular Immunology / Instituto de Investigação e Inovação da Universidade do Porto, Portugal.
Helena AlvesINSA, National Institute of Health Dr. Ricardo Jorge, Porto, Portugal.

Funding

BREAST CANCER/BONE MARROW STROMAL INTERACTIONSR01CA089868 · NCI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI RAMESHWAR, PRANELA · 2000 to 2003
$873k
NCI NIH HHS R01 CA089868
6 · The paper itself

Abstract

Recent evidences demonstrated the importance of bone marrow derived Endothelial Progenitor Cells (EPC), in the contribution to postnatal physiological and pathological neovascularization, and in tumor growth and angiogenesis. These cells are recruited undifferentiated, in response to systemic or chemoatractive signals, such as Vascular Endothelial Growth Factor (VEGF), they lodge in the growing or lesioned tissue and differentiate into endothelial cells in response to local stimuli and cell-cell interactions. The extent and the significance of the EPCs contribution for the growing of most tumors, including those of the breast, are still not fully defined. We analyzed the peripheral blood of breast cancer patients and found that they have circulating EPCs. We also found an association between expression of AC133+Kdr+ and VEGF plasma levels in these patients. Strategies to impair the mobilization and incorporation of EPCs into breast tumors may contribute to halt the growth of these tumors.

Indexed as

AC133Breast cancerEndothelial progenitor cellsKDRVEGF

Identifiers

PMID26878074
PMCPMC4751051

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.