Evidence map›Paper›PMID 26877886›Full record

ArticleAntibiotics (Basel, Switzerland)2015

Pharmacokinetic/Toxicity Properties of the New Anti-Staphylococcal Lead Compound SK-03-92.

William R Schwan, Jill M Kolesar, M Shahjahan Kabir, Edmund J Elder, Jeffrey B Williams, Rachel Minerath, James M Cook, Christopher M Witzigmann, Aaron Monte, Tricia Flaherty

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. SK-03-92 Drug Kills IntracellularAntibiotics (Basel, Switzerland) · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

William R SchwanDepartment of Microbiology, University of Wisconsin-La Crosse, 1725 State St., La Crosse, WI 54601, USA; Emerging Technology Center for Pharmaceutical Development, University of Wisconsin-La Crosse, 1725 State St., La Crosse, WI 54601, USA.
Jill M KolesarCarbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, WI 53706, USA.
M Shahjahan KabirDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
Edmund J ElderZeeh Pharmaceutical Experiment Station, University of Wisconsin-Madison, Madison, WI 53705, USA.
Jeffrey B WilliamsZeeh Pharmaceutical Experiment Station, University of Wisconsin-Madison, Madison, WI 53705, USA.
Rachel MinerathDepartment of Microbiology, University of Wisconsin-La Crosse, 1725 State St., La Crosse, WI 54601, USA.
James M CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
Christopher M WitzigmannDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
Aaron MonteEmerging Technology Center for Pharmaceutical Development, University of Wisconsin-La Crosse, 1725 State St., La Crosse, WI 54601, USA; Department of Chemistry and Biochemistry, University of Wisconsin-La Crosse, 1725 State St., La Crosse, WI 54601, USA.
Tricia FlahertyDepartment of Microbiology, University of Wisconsin-La Crosse, 1725 State St., La Crosse, WI 54601, USA.

Funding

Development of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0M
Synthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3M
NHLBI NIH HHS R01 HL118561NINDS NIH HHS R01 NS076517
6 · The paper itself

Abstract

Because of the potential of a new anti-staphylococcal lead compound SK-03-92 as a topical antibiotic, a patch, or an orally active drug, we sought to determine its safety profile and oral bioavailability. SK-03-92 had a high IC

Indexed as

drug formulationpharmacokineticssafety testingStaphylococcus

Identifiers

PMID26877886
PMCPMC4748848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.