ArticleIranian journal of basic medical sciences2015
Effects of gamma oryzanol on factors of oxidative stress and sepsis-induced lung injury in experimental animal model.
Article in Iranian journal of basic medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Gamma-oryzanol dose optimization in maturation or culture media forIranian journal of veterinary research · 2023Article
- Taurine in Septic Critically Ill Patients: Plasma versus Blood.Advanced pharmaceutical bulletin · 2023Article
- Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis.Pharmaceutical biology · 2022Article
- Comparative study of gavage and intraperitoneal administration of gamma-oryzanol in alleviation/attenuation in a rat animal model of renal ischemia/reperfusion-induced injury.Iranian journal of basic medical sciences · 2021Article
- ORY supplementation mitigates acetaminophen-induced acute liver failure in male mice: role of oxidative stress and apoptotic markers.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Ziziphus spina-christi leaf extract pretreatment inhibits liver and spleen injury in a mouse model of sepsis via anti-oxidant and anti-inflammatory effects.Inflammopharmacology · 2018Article
- Metformin-attenuated sepsis-induced oxidative damages: a novel role for metformin.Iranian journal of basic medical sciences · 2018Article
- Screening of Anti-Malarial Activity of Different Extracts Obtained from Three Species ofIranian journal of pharmaceutical research : IJPR · 2018Article
- Effect of Gamma-Oryzanol as Therapeutic Agent to Prevent Cardiorenal Metabolic Syndrome in Animals Submitted to High Sugar-Fat Diet.Nutrients · 2017Article
- 5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice.Mediators of inflammation · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective sThere is corroborating evidence to substantiate redox imbalance and oxidative stress in sepsis that finally leads to organ damage or even death. Gamma oryzanol (GO) is one of the major bioactive components in rice bran has been considered to function as an antioxidant. The present study was carried out to evaluate the antioxidant activity of gamma oryzanol in vitro and its efficacy in sepsis. MATERIALS AND
methodsTo induce sepsis, cecal ligation and puncture (CLP) method was performed on the rats. A study group of forty male Wistar rats were divided into the following groups: sham group; CLP group; 50 mg/kg GO- treated CLP group and 100 mg/kg GO- treated CLP group. GO was administered with an oral gavage 2 hr prior to inducing sepsis. Tissue and blood samples were collected 12 hr after CLP to prepare tissue sections for histopathological study and assay the oxidative stress biomarkers including: SOD (Superoxide Dismutase), TAC (total antioxidant capacity), MDA (Malondialdehyde), MPO (Myeloperoxidase) and PAI-1 (Plasminogen Activator Inhibitor-1). Data are given as mean ± SD. The ANOVA with Tukey post hoc test was used to determine the differences between groups and P <0.05 was considered as statistical significance.
resultsTAC level increased in GO- treated CLP groups (P<0.05). Inflammation score of lung tissue and MPO activity were significantly lower in GO treated CLP group (P<0.05).
conclusionIt seems that GO has a protective effect on lung inflammation and improves the body redox capacity during sepsis.
Indexed as
Identifiers
26877858PMC4744368W2228924701What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.