ArticleIranian journal of psychiatry2015
Anxiety Assessment in Methamphetamine - Sensitized and Withdrawn Rats: Immediate and Delayed Effects.
Article in Iranian journal of psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Intraperitoneal injection of buprenorphine on anxiety-like behavior and alteration in expression ofVeterinary research forum : an international quarterly journal · 2022Article
- Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKMζ and increased κOR in the hippocampus of female mice.Journal of psychopharmacology (Oxford, England) · 2021Article
- Methamphetamine exposure and its cessation alter gut microbiota and induce depressive-like behavioral effects on rats.Psychopharmacology · 2021Article
- Effects of Buprenorphine on the Memory and Learning Deficit Induced by Methamphetamine Administration in Male Rats.Frontiers in behavioral neuroscience · 2021Article
- Methamphetamine self-administration in a runway model of drug-seeking behavior in male rats.Pharmacology, biochemistry, and behavior · 2018Article
- Effect of three different regimens of repeated methamphetamine on rats' cognitive performance.Cognitive processing · 2018Article
- Methamphetamine-alcohol interactions in murine models of sequential and simultaneous oral drug-taking.Drug and alcohol dependence · 2017Article
- Comparing the Antinociceptive Effects of Methamphetamine, Buprenorphine, or Both After Chronic Treatment and Withdrawal in Male Rats.Basic and clinical neuroscienceArticle
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Authors and funding
3 authors.
Funding
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Abstract
objectiveThe anxiety profile in the stimulant-sensitized animals is not clear. Thus, this study was conducted to elucidate the effects of acute and chronic administration of methamphetamine (METH) on the anxiety profile. The aim of this study was to examine whether METH-sensitized rats would show an increase in the expression of anxiogenic-like behaviors and to determine whether a low dose of METH elicits behavioral sensitization.
methodsRats were repeatedly given METH (2 mg/kg, s.c., once a day for 14 days), and the immediate and delayed effects of METH on the anxiety profile was compared considering 30 minutes (min) and 120 min after injections in METH-sensitized, withdrawn and intact rats using the elevated plus-maze (EPM), also, to re-challenge with a low dose of METH (0.5 mg/kg) in withdrawn groups.
resultsRESULTS have shown that METH-sensitized rats exhibited an increase in the open arm time and entries 120 min after injection compared to the control group. We found a reduction in the time spent in open arms for the immediate effects of METH (30 min after injection) in METH-sensitized rats as compared to the control group. In withdrawn rats, METH/METH groups exhibited an increase in the open arm time and entries than METH/Sal and Sal/METH groups.
conclusionIt was found that unlike delayed effects, an immediate effect of METH exhibited anxiogenic-like behaviors in METH-sensitized rats using the EPM. Also, results indicated that a low dose of METH is a potent stimulus for reinstatement of methamphetamine behavioral sensitization in a long withdrawn period.
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Identifiers
26877748PMC4749684What OpenQuestion holds
Registered trials
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