ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2016
Post-vaccination myositis and myocarditis in a previously healthy male.
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Severe manifestations of autoimmune syndrome induced by adjuvants (Shoenfeld's syndrome).Immunologic research · 2017Pooled it
- A Rare Case of Toxic Myositis Associated with Influenza Vaccination.Journal of community hospital internal medicine perspectives · 2024Article
- A Study on the Self-Reported Physician-Diagnosed Cardiac Complications Post mRNA Vaccination in Saudi Arabia.Cureus · 2024Article
- Comparison of COVID-19 Vaccine-Associated Myocarditis and Viral Myocarditis Pathology.Vaccines · 2023Review
- COVID-19 Vaccination in Autoimmune Diseases (COVAD) study: Vaccine safety in idiopathic inflammatory myopathies.Muscle & nerve · 2022Article
- Article
- COVID-19 vaccine-associated myositis - a case report.Clinical case reports · 2022Article
- Recurring Weakness in Rhabdomyolysis Following Pfizer-BioNTech Coronavirus Disease 2019 mRNA Vaccination.Vaccines · 2022Article
- Two Cases of Acute Myocarditis in Young Male Adults After mRNA Vaccines Against COVID-19: Similarities and Differences.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022Article
- Rhabdomyolysis after BNT162b2 mRNA Covid-19 vaccine in an adolescent male.Malawi medical journal : the journal of Medical Association of Malawi · 2022Article
- Article
- Review
- Myocarditis following rAd26 and rAd5 vector-based COVID-19 vaccine: case report.ESC heart failure · 2022Article
- Article
- Review
- Article
- Cardiac Manifestations of Multisystem Inflammatory Syndrome in Children (MIS-C) Following COVID-19.Current cardiology reports · 2021Review
- Myocarditis, Pericarditis and Cardiomyopathy After COVID-19 Vaccination.Heart, lung & circulation · 2021Article
- Case report: acute myocarditis following the second dose of mRNA-1273 SARS-CoV-2 vaccine.European heart journal. Case reports · 2021Article
- Vaccination as a possible trigger for immune-mediated necrotising myopathy.BMJ case reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe immunological literature has been redefining clinical phenomena as hypotheses emerge regarding causal links between triggers, immunologic manifestations, and their specific inflammatory cascades. Of late, autoimmune manifestations that appear to be caused by an external adjuvant have been grouped into a complex syndrome referred to as autoimmune/inflammatory syndrome induced by adjuvants (ASIA). This syndrome may present with diverse clinical problems, which may include neurocognitive impairment, inflammatory musculoskeletal changes, and constitutional symptoms. There is evidence in the literature linking vaccines to different auto-immune manifestations. Vaccines have not traditionally been reported to trigger ASIA, although reports are emerging linking the human papilloma virus and hepatitis B vaccines to it. CASE PRESENTATION: We report the first suspected case of ASIA in a previously healthy patient who received the Fluad seasonal influenza vaccine, which contains the MF59 adjuvant. He presented to hospital with profound weakness and was diagnosed with severe rhabdomyolysis. He also had elevated troponin-I and extensive cardiac investigations enabled the diagnosis of myocarditis. His infectious and rheumatologic work-ups were negative. He responded well to conservative management and did not require immune suppressive therapy.
conclusionGiven the benefits of the influenza vaccine, and the low incidence of clinically significant complications, we encourage ongoing seasonal influenza immunization. However, ongoing surveillance is required to evaluate the occurrence of rare adverse events, including ASIA.
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