Evidence map›Paper›PMID 26877612›Full record

ArticleWorld journal of gastroenterology2016

Interleukin-22 contributes to liver regeneration in mice with concanavalin A-induced hepatitis after hepatectomy.

Ya-Min Zhang, Zi-Rong Liu, Zi-Lin Cui, Chao Yang, Long Yang, Yang Li, Zhong-Yang Shen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Interleukin 22 in Liver Injury, Inflammation and Cancer.International journal of biological sciences · 2020
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ya-Min ZhangYa-Min Zhang, Zi-Lin Cui, Long Yang, Yang Li, Zhong-Yang Shen, Department of Hepatobiliary Surgery, First Central Hospital, Tianjin 300192, China.
Zi-Rong LiuYa-Min Zhang, Zi-Lin Cui, Long Yang, Yang Li, Zhong-Yang Shen, Department of Hepatobiliary Surgery, First Central Hospital, Tianjin 300192, China.
Zi-Lin CuiYa-Min Zhang, Zi-Lin Cui, Long Yang, Yang Li, Zhong-Yang Shen, Department of Hepatobiliary Surgery, First Central Hospital, Tianjin 300192, China.
Chao YangYa-Min Zhang, Zi-Lin Cui, Long Yang, Yang Li, Zhong-Yang Shen, Department of Hepatobiliary Surgery, First Central Hospital, Tianjin 300192, China.
Long YangYa-Min Zhang, Zi-Lin Cui, Long Yang, Yang Li, Zhong-Yang Shen, Department of Hepatobiliary Surgery, First Central Hospital, Tianjin 300192, China.
Yang LiYa-Min Zhang, Zi-Lin Cui, Long Yang, Yang Li, Zhong-Yang Shen, Department of Hepatobiliary Surgery, First Central Hospital, Tianjin 300192, China.
Zhong-Yang ShenYa-Min Zhang, Zi-Lin Cui, Long Yang, Yang Li, Zhong-Yang Shen, Department of Hepatobiliary Surgery, First Central Hospital, Tianjin 300192, China.
Tianjin First Center Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the therapeutic effects and mechanisms of interleukin (IL)-22 in liver regeneration in mice with concanavalin A (ConA)-induced liver injury following 70% hepatectomy.

methodsMice were injected intravenously with ConA at 10 μg/g body weight 4 d before 70% hepatectomy to create a hepatitis model, and recombinant IL-22 was injected at 0.125 μg/g body weight 30 min prior to 70% hepatectomy to create a therapy model. Control animals received an intravenous injection of an identical volume of normal saline.

resultsIL-22 treatment prior to 70% hepatectomy performed under general anesthesia resulted in reductions in the biochemical and histological evidence of liver injury, earlier proliferating cell nuclear antigen expression and accelerated recovery of liver mass. IL-22 pretreatment also significantly induced signal transducer and activator of transcription factor 3 (STAT3) activation and increased the expression of a variety of mitogenic proteins, such as Cyclin D1. Furthermore, alpha fetal protein mRNA expression was significantly elevated after IL-22 treatment.

conclusionIn this study, we demonstrated that IL-22 is a survival factor for hepatocytes and prevents and repairs liver injury by enhancing pro-growth pathways via STAT3 activation. Treatment with IL-22 protein may represent a novel therapeutic strategy for preventing liver injury in patients with liver disease who have undergone hepatectomy.

Indexed as

Concanavalin AHepatectomyLiver Regenerationalpha-FetoproteinsAnimalsCell Cycle ProteinsCell ProliferationChemical and Drug Induced Liver InjuryDisease Models, AnimalFemaleInjections, IntravenousInterleukin-22InterleukinsLiverMice, Inbred C57BLSignal Transductionalpha-FetoproteinsCell Cycle ProteinsConcanavalin AInterleukin-22InterleukinsStat3 protein, mouseSTAT3 Transcription FactorConcanavalin AInterleukin-22Liver regenerationPartial hepatectomy

Identifiers

PMID26877612
PMCPMC4726680
OpenAlexW2473565432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.