ArticleMolecular pharmaceutics2016
Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization.
Article in Molecular pharmaceutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs.International journal of pharmaceutics: X · 2022Article
- Effect of Surfactants and Polymers on the Dissolution Behavior of Supersaturable Tecovirimat-4-Hydroxybenzoic Acid Cocrystals.Pharmaceutics · 2021Article
- Pharmaceutical cocrystals: A review of preparations, physicochemical properties and applications.Acta pharmaceutica Sinica. B · 2021Review
- Engineering Cocrystals of PoorlyWater-Soluble Drugs to Enhance Dissolution in Aqueous Medium.Pharmaceutics · 2018Review
- Cocrystals Mitigate Negative Effects of High pH on Solubility and Dissolution of a Basic Drug.Crystal growth & design · 2018Article
- Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments.Pharmaceutical research · 2018Article
- Mechanistic Basis of Cocrystal Dissolution Advantage.Journal of pharmaceutical sciences · 2018Article
- Cocrystals to facilitate delivery of poorly soluble compounds beyond-rule-of-5.Advanced drug delivery reviews · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The purpose of this work is to provide a mechanistic understanding of the dissolution behavior of cocrystals under the influence of ionization and micellar solubilization. Mass transport models were developed by applying Fick's law of diffusion to dissolution with simultaneous chemical reactions in the hydrodynamic boundary layer adjacent to the dissolving cocrystal surface to predict the pH at the dissolving solid-liquid interface (i.e., interfacial pH) and the flux of cocrystals. To evaluate the predictive power of these models, dissolution studies of carbamazepine-saccharin (CBZ-SAC) and carbamazepine-salicylic acid (CBZ-SLC) cocrystals were performed at varied pH and surfactant concentrations above the critical stabilization concentration (CSC), where the cocrystals were thermodynamically stable. The findings in this work demonstrate that the pH dependent dissolution behavior of cocrystals with ionizable components is dependent on interfacial pH. This mass transport analysis demonstrates the importance of pH, cocrystal solubility, diffusivity, and micellar solubilization on the dissolution rates of cocrystals.
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Registered trials
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