Evidence map›Paper›PMID 26877223›Full record

ArticleCell stem cell2016

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors.

Pratik A Lalit, Max R Salick, Daryl O Nelson, Jayne M Squirrell, Christina M Shafer, Neel G Patel, Imaan Saeed, Eric G Schmuck, Yogananda S Markandeya, Rachel Wong and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
17.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 173 citations in OpenAlex.

  1. Regenerative therapy · 2026
    Article
  2. Review
  3. Review
  4. Article
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  7. Article
  8. Review
  9. Article
  10. Fibroblast Reprogramming in Cardiac Repair.JACC. Basic to translational science · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Cellular reprogramming of fibroblasts in heart regeneration.Journal of molecular and cellular cardiology · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Pratik A LalitDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; Molecular and Cellular Pharmacology Program, University of Wisconsin-Madison, Madison, WI 53705, USA; Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Max R SalickDepartment of Engineering Physics, University of Wisconsin-Madison, Madison, WI 53705, USA; Wisconsin Institutes for Discovery, University of Wisconsin-Madison, Madison, WI 53705, USA; Material Science Program, University of Wisconsin-Madison, Madison, WI 53705, USA.
Daryl O NelsonStem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Jayne M SquirrellStem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI 53705, USA.
Christina M ShaferMorgridge Institute for Research, University of Wisconsin-Madison, Madison, WI 53705, USA.
Neel G PatelDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Imaan SaeedDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Eric G SchmuckDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Yogananda S MarkandeyaDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Rachel WongDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Martin R LeaDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA.
Kevin W EliceiriStem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Laboratory for Optical and Computational Instrumentation, University of Wisconsin-Madison, Madison, WI 53705, USA.
Timothy A HackerDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA.
Wendy C CroneStem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Engineering Physics, University of Wisconsin-Madison, Madison, WI 53705, USA; Wisconsin Institutes for Discovery, University of Wisconsin-Madison, Madison, WI 53705, USA; Material Science Program, University of Wisconsin-Madison, Madison, WI 53705, USA.
Michael KybaDepartment of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA; Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Daniel J GarryDepartment of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Ron StewartMorgridge Institute for Research, University of Wisconsin-Madison, Madison, WI 53705, USA.
James A ThomsonStem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA; Morgridge Institute for Research, University of Wisconsin-Madison, Madison, WI 53705, USA.
Karen M DownsStem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Gary E LyonsStem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA.
Timothy J KampDepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USA; Molecular and Cellular Pharmacology Program, University of Wisconsin-Madison, Madison, WI 53705, USA; Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: tjk@medicine.wisc.edu.
University of Wisconsin–Madison · USUniversity of Wisconsin System · USUniversity of Minnesota · US

Funding

ZOLEDRONATE PREVENTS BONE LOSS IN OVARIECTOMIZED RHESUS MONKEYSP51RR000167 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 1985 to 2011
$106.7M
Midwest Progenitor Cell ConsortiumU01HL099773 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI THOMSON, JAMES ALEXANDER · 2009 to 2015
$7.8M
Midwestern Progenitor Cell ConsortiumU01HL100407 · NHLBI · UNIVERSITY OF MINNESOTA · PI GARRY, DANIEL J., KYBA, MICHAEL · 2009 to 2015
$7.8M
Morphogenesis of the chorio-allantoic placenta II: The Allantoic Core DomainR01HD042706 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI DOWNS, KAREN M · 2002 to 2012
$3.0M
The fetal-umbilical connection: role of hypoblast/visceral endodermR01HD079481 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI GREENSPAN, DANIEL S · 2014 to 2018
$1.5M
Refining Cardiac Progenitor Cells for Myocardial RepairR01HL129798 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI KAMP, TIMOTHY J. · 2015 to 2018
$1.5M
Olympus FV1000 Livecell Confocal SystemS10RR025644 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI KAMP, TIMOTHY J. · 2011 to 2011
$433k
NCRR NIH HHS P51 RR000167NCRR NIH HHS S10 RR025644NCRR NIH HHS S10RR025644NHLBI NIH HHS R01 HL129798NHLBI NIH HHS U01 HL099773NHLBI NIH HHS U01HL099773NHLBI NIH HHS U01 HL100407NICHD NIH HHS R01 HD079481NICHD NIH HHS R01 HD42706
6 · The paper itself

Abstract

Several studies have reported reprogramming of fibroblasts into induced cardiomyocytes; however, reprogramming into proliferative induced cardiac progenitor cells (iCPCs) remains to be accomplished. Here we report that a combination of 11 or 5 cardiac factors along with canonical Wnt and JAK/STAT signaling reprogrammed adult mouse cardiac, lung, and tail tip fibroblasts into iCPCs. The iCPCs were cardiac mesoderm-restricted progenitors that could be expanded extensively while maintaining multipotency to differentiate into cardiomyocytes, smooth muscle cells, and endothelial cells in vitro. Moreover, iCPCs injected into the cardiac crescent of mouse embryos differentiated into cardiomyocytes. iCPCs transplanted into the post-myocardial infarction mouse heart improved survival and differentiated into cardiomyocytes, smooth muscle cells, and endothelial cells. Lineage reprogramming of adult somatic cells into iCPCs provides a scalable cell source for drug discovery, disease modeling, and cardiac regenerative therapy.

Indexed as

Cell ProliferationCellular ReprogrammingAnimalsCell SurvivalCellular Reprogramming TechniquesFibroblastsMiceMice, TransgenicMyoblasts, CardiacTranscription FactorsTranscription Factors

Identifiers

PMID26877223
PMCPMC4779406
OpenAlexW2262375366

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.