Evidence map›Paper›PMID 26877209›Full record

ArticleScientific reports2016

Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote.

Jingjing Jiang, Adriano Chan, Sameh Ali, Arindam Saha, Kristofer J Haushalter, Wai-Ling Macrina Lam, Megan Glasheen, James Parker, Matthew Brenner, Sari B Mahon and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed
21.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 278 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Hydrogen (HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Jingjing JiangDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Adriano ChanDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Sameh AliDepartment of Anesthesiology, University of California San Diego, La Jolla, California, USA.
Arindam SahaDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Kristofer J HaushalterDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA.
Wai-Ling Macrina LamDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Megan GlasheenDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
James ParkerNeurodegenerative Disease Center, The Scintillon Institute, San Diego, California, USA.
Matthew BrennerBeckman Laser Institute, University of California Irvine, Irvine, California, USA.
Sari B MahonBeckman Laser Institute, University of California Irvine, Irvine, California, USA.
Hemal H PatelDepartment of Anesthesiology, University of California San Diego, La Jolla, California, USA.
Rajesh AmbasudhanNeurodegenerative Disease Center, The Scintillon Institute, San Diego, California, USA.
Stuart A LiptonNeurodegenerative Disease Center, The Scintillon Institute, San Diego, California, USA.
Renate B PilzDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
Gerry R BossDepartment of Medicine, University of California San Diego, La Jolla, California, USA.
University of California, San Diego · USScintillon Institute · USBeckman Laser Institute and Medical Clinic · USVA San Diego Healthcare System · US

Funding

Pre-Clinical and Clinical Studies of Cobinamide, A New Cyanide Detoxifying AgentU01NS058030 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2006 to 2017
$7.3M
Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide AntidoteU01NS087964 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2015 to 2019
$4.3M
Physician-Scientist Research Training ProgramT32DK069263 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2005 to 2015
$2.5M
Protection of the Aged MyocardiumR01HL107200 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATEL, HEMAL H, ROTH, DAVID M · 2011 to 2014
$2.1M
Modeling Parkinson's Disease with Isogenic hiPSC-Derived Dopaminergic NeuronsR01NS086890 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI LIPTON, STUART A · 2014 to 2018
$2.1M
Protection of Brain Injury from Cyanide Poisoning by Carnosic AcidR21NS080799 · NINDS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI LIPTON, STUART A · 2012 to 2013
$975k
Testing the Vitamin B12 Analog Cobinamide Against Selected Chemical ThreatsR21NS072105 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOSS, GERRY R · 2011 to 2012
$774k
Novel Therapeutics for Diabetic CardiomyopathyI01BX001963 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI PATEL, HEMAL H · 2013 to 2025
–
BLRD VA I01 BX001963NHLBI NIH HHS HL107200NHLBI NIH HHS R01 HL107200NIDDK NIH HHS T32 DK069263NIDDK NIH HHS T32DK069263NINDS NIH HHS R01 NS086890NINDS NIH HHS R21 NS072105NINDS NIH HHS R21NS072105NINDS NIH HHS R21 NS080799NINDS NIH HHS R21NS080799NINDS NIH HHS U01 NS058030NINDS NIH HHS U01 NS087964
6 · The paper itself

Abstract

Hydrogen sulfide is a highly toxic gas-second only to carbon monoxide as a cause of inhalational deaths. Its mechanism of toxicity is only partially known, and no specific therapy exists for sulfide poisoning. We show in several cell types, including human inducible pluripotent stem cell (hiPSC)-derived neurons, that sulfide inhibited complex IV of the mitochondrial respiratory chain and induced apoptosis. Sulfide increased hydroxyl radical production in isolated mouse heart mitochondria and F2-isoprostanes in brains and hearts of mice. The vitamin B12 analog cobinamide reversed the cellular toxicity of sulfide, and rescued Drosophila melanogaster and mice from lethal exposures of hydrogen sulfide gas. Cobinamide worked through two distinct mechanisms: direct reversal of complex IV inhibition and neutralization of sulfide-generated reactive oxygen species. We conclude that sulfide produces a high degree of oxidative stress in cells and tissues, and that cobinamide has promise as a first specific treatment for sulfide poisoning.

Indexed as

AnimalsAntidotesApoptosisBrainCell DifferentiationCobamidesDrosophila melanogasterElectron Transport Complex IVF2-IsoprostanesFibroblastsHumansHydrogen SulfideHydroxyl RadicalInduced Pluripotent Stem CellsMaleMiceAntidotesCobamidescobinamideElectron Transport Complex IVF2-IsoprostanesHydrogen SulfideHydroxyl RadicalPotassium Cyanidesodium bisulfideSulfides

Identifiers

PMID26877209
PMCPMC4753484
OpenAlexW2339511459

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.