Evidence map›Paper›PMID 26877127›Full record

ArticlePsychophysiology2016

Neuroethology as a translational neuroscience strategy in the era of the NIMH Research Domain Criteria.

John H Krystal

Abstract readComment
In one paragraph

Article in Psychophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

John H KrystalDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
Translational Technologies CoreP50AA012870 · NIAAA · YALE UNIVERSITY · PI John H. Krystal · 2001 to 2026
$43.7M
ZIPRASIDONE IN TOURETTES SYNDROME, OBSESSIVE COMPULSIVE &PERVASIVE DEV. DISORDERM01RR000125 · NCRR · YALE UNIVERSITY · PI ALPERN, ROBERT J · 1985 to 2006
$24.1M
Translational Neuroscience Optimization of GlyT1 InhibitorUH2TR000960 · NCATS · YALE UNIVERSITY · PI KRYSTAL, JOHN H. · 2013 to 2014
$2.2M
Intramural VA VA999999NCATS NIH HHS 1UH2TR000960-01NCATS NIH HHS UH2 TR000960NCRR NIH HHS M01 RR000125NCRR NIH HHS M01RR00125NCRR NIH HHS UL1 RR024139NIAAA NIH HHS P50 AA012870NIAAA NIH HHS P50AA12870
6 · The paper itself

Abstract

The article by Latzman et al. in the current special issue utilizes a novel dataset consisting of behavioral, brain, and genomic data from a sample of 76 captive chimpanzees to make the case that negative affective expression is influenced by variation in the gene coding for arginine vasopressin receptor 1A (AVPR1A), in a sex-linked manner. A novel feature of this study is the ethological approach employed by the authors, i.e., the use of scratching as a behavioral indicator of negative affective state. I comment on conceptual and methodological aspects of this work, and consider how it interfaces with the Research Domain Criteria (RDoC) framework as described by Kozak and Cuthbert in their article for this issue.

Indexed as

National Institute of Mental Health (U.S.)NeurosciencesBrainHumansReceptors, VasopressinResearchReceptors, Vasopressin

Identifiers

PMID26877127
PMCPMC4758465

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.