ReviewPsychophysiology2016
Panic disorder with agoraphobia from a behavioral neuroscience perspective: Applying the research principles formulated by the Research Domain Criteria (RDoC) initiative.
Review in Psychophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Does prior traumatization affect the treatment outcome of CBT for panic disorder? The potential role of the MAOA gene and depression symptoms.European archives of psychiatry and clinical neuroscience · 2019Trial
- Fear Circuits in Panic Disorder: An Update.Alpha psychiatry · 2025Review
- The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025Review
- Understanding anxiety symptoms as aberrant defensive responding along the threat imminence continuum.Neuroscience and biobehavioral reviews · 2023Review
- Coping in the Clinic: Effects of Clinically Elevated Anxiety on Dynamic Neurophysiological Mechanisms of Escape/Avoidance Preparation.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Review
- Qualitative and quantitative evidence of motivation states for physical activity, exercise and being sedentary from university student focus groups.Frontiers in sports and active living · 2023Article
- Mood and anxiety disorders within the Research Domain Criteria framework of Positive and Negative Valence Systems: a scoping review.Frontiers in human neuroscience · 2023Article
- Recognition memory, primacy vs. recency effects, and time perception in the online version of the fear of scream paradigm.Scientific reports · 2022Article
- Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience.Clinical psychology review · 2021Review
- Vagal control of the heart decreases during increasing imminence of interoceptive threat in patients with panic disorder and agoraphobia.Scientific reports · 2021Article
- Panic disorder: attack of fear or acute attack of solitude? Convergences between affective neuroscience and phenomenological-Gestalt perspective.Research in psychotherapy (Milano) · 2020Article
- Towards a Clinically Valid Mechanistic Assessment of Exposure and Response Prevention: Preliminary Utility of an Exposure Learning Tool for Children with OCD.Journal of obsessive-compulsive and related disorders · 2020Article
- Anxiety and Startle Phenotypes inFrontiers in molecular neuroscience · 2020Article
- Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning.Neuroscience and biobehavioral reviews · 2019Review
- Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.Translational psychiatry · 2019Article
- A Novel Bio-Psychosocial-Behavioral Treatment Model of Panic Disorder.Psychiatry investigation · 2019Article
- Article
- A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety.Translational psychiatry · 2018Article
- Avoidance and escape: Defensive reactivity and trait anxiety.Behaviour research and therapy · 2018Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the current review, we reconceptualize a categorical diagnosis-panic disorder and agoraphobia-in terms of two constructs within the domain "negative valence systems" suggested by the Research Domain Criteria initiative. Panic attacks are considered as abrupt and intense fear responses to acute threat arising from inside the body, while anxious apprehension refers to anxiety responses to potential harm and more distant or uncertain threat. Taking a dimensional view, panic disorder with agoraphobia is defined with the threat-imminence model stating that defensive responses are dynamically organized along the dimension of the proximity of the threat. We tested this model within a large group of patients with panic disorder and agoraphobia (N = 369 and N = 124 in a replication sample) and found evidence that panic attacks are indeed instances of circa strike defense. This component of the defensive reactivity was related to genetic modulators within the serotonergic system. In contrast, anxious apprehension-characterized by attentive freezing during postencounter defense-was related to general distress and depressive mood, as well as to genetic modulations within the hypothalamic-pituitary-adrenal (HPA) axis. Patients with a strong behavioral tendency for active and passive avoidance responded better to exposure treatment if the therapist guides the patient through the exposure exercises.
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Registered trials
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