ArticleCurrent biology : CB2016
ER-PM Contacts Define Actomyosin Kinetics for Proper Contractile Ring Assembly.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stay in touch with the endoplasmic reticulum.Science China. Life sciences · 2024Pooled it
- The ER-PM interaction is essential for cytokinesis and recruits the actin cytoskeleton through the SCAR/WAVE complex.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exocytic plasma membrane flows remodel endoplasmic reticulum-plasma membrane tethering for septin collar assembly.Science advances · 2024Article
- Anillin-related Mid1 as an adaptive and multimodal contractile ring anchoring protein: A simulation study.Structure (London, England : 1993) · 2024Article
- Article
- Geometry and cellular function of organelle membrane interfaces.Plant physiology · 2021Review
- Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum.Communications biology · 2020Article
- Organization of associating or crosslinked actin filaments in confinement.Cytoskeleton (Hoboken, N.J.) · 2019Article
- Mobility of Molecular Motors Regulates Contractile Behaviors of Actin Networks.Biophysical journal · 2019Article
- Multiscale model of integrin adhesion assembly.PLoS computational biology · 2019Article
- Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cortical actin contributes to spatial organization of ER-PM junctions.Molecular biology of the cell · 2017Article
- A lipid regulator working at the cleavage furrow.Cell cycle (Georgetown, Tex.) · 2016Article
- Via Proteins and Lipids - Versatility of VAPs at Dynamic Membrane Contact Sites.Contact (Thousand Oaks (Ventura County, Calif.))Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The cortical endoplasmic reticulum (ER), an elaborate network of tubules and cisternae [1], establishes contact sites with the plasma membrane (PM) through tethering machinery involving a set of conserved integral ER proteins [2]. The physiological consequences of forming ER-PM contacts are not fully understood. Here, we reveal a kinetic restriction role of ER-PM contacts over ring compaction process for proper actomyosin ring assembly in Schizosaccharomyces pombe. We show that fission yeast cells deficient in ER-PM contacts exhibit aberrant equatorial clustering of actin cables during ring assembly and are particularly susceptible to compromised actin filament crosslinking activity. Using quantitative image analyses and computer simulation, we demonstrate that ER-PM contacts function to modulate the distribution of ring components and to constrain their compaction kinetics. We propose that ER-PM contacts have evolved as important physical modulators to ensure robust ring assembly.
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